Actively Recruiting
Evaluating the Effect of Intravenous Dexamethasone on the Duration of Spinal Anesthesia After Cesarean Delivery
Led by IWK Health Centre · Updated on 2024-07-08
192
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine the effects of intravenous (IV) dexamethasone on spinal anesthesia in healthy women having an elective Cesarean delivery (CD) at the IWK Health Centre. The main questions it aims to answer are: 1. What effect does IV dexamethasone have on the resolution of motor blockade in patients having spinal anesthesia for elective CDs? 2. What effect does IV dexamethasone have on the sensory recovery of spinal blockade, the total hydromorphone requirement in the first 24 h postoperatively, the incidence of pruritis perioperatively, and the incidence of nausea and vomiting? The spinal anesthesia technique will be standardized and will be administered as per routine care at IWK Health. Computer generation will randomize patients to either Group SD, who will receive IV dexamethasone, or group SM who will receive IV metoclopramide, an alternative anti-emetic, immediately after spinal anesthesia by the attending anesthesia provider. Each patient will receive ondansetron, a second anti- emetic as recommended for Enhanced Recovery After Surgery (ERAS) protocol. Participant sensation, pain, nausea, pruritus, and motor blockade will be assessed in recovery. The patient's sensation and Bromage score will be assessed every 15 minutes until sensation is reached at L3 and a Bromage score of 4 is achieved. The investigators will determine if there is a difference between groups regarding motor blockade, the length of time of spinal anesthesia, and side effects after CD.
CONDITIONS
Official Title
Evaluating the Effect of Intravenous Dexamethasone on the Duration of Spinal Anesthesia After Cesarean Delivery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-emergent Cesarean Delivery with planned spinal anesthesia
- American Society of Anesthesia physical status class less than III
- Age 18 years or older
- Term pregnancy at 37 weeks or more
- Singleton pregnancy
- Moderate fluency in English
You will not qualify if you...
- Obesity with BMI 45 kg/m2 or higher
- Height less than 5 feet
- Significant obstetric or neonatal health issues such as severe maternal cardiac disease, preeclampsia, or fetal anomalies
- Opioid tolerance or sensitivity
- Intolerance to non-steroidal anti-inflammatory drugs (NSAIDs)
- Contraindications to neuraxial analgesia such as coagulopathy, infection, or neuropathy
- Abnormal spinal anatomy including severe scoliosis, spina bifida, or spinal instrumentation
- Use of chronic steroids
- Physical or psychiatric conditions that impair cooperation
AI-Screening
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Trial Site Locations
Total: 1 location
1
IWK Health Centre
Halifax, Nova Scotia, Canada, B3K 6R8
Actively Recruiting
Research Team
A
Allana Munro, MD FRCPC
CONTACT
K
Kwesi Kwofie, MD FRCPC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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