Actively Recruiting
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer
Led by Dallas VA Medical Center · Updated on 2021-11-04
78
Participants Needed
1
Research Sites
379 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Esophageal cancer, which has a low 5-year overall survival rate for all stages (\<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to inhibit various pathways involved in esophageal cancer tumorigenesis including Hh and AKT. In this phase II clinical trial, the investigators aim to evaluate the effect of itraconazole as a neoadjuvant therapy following standard of care chemoradiation in the treatment of locoregional esophageal and gastroesophageal junction carcinomas.
CONDITIONS
Official Title
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with localized (locoregional) esophageal cancer
- Patients diagnosed with localized (locoregional) gastroesophageal junction cancer
You will not qualify if you...
- Patients unwilling or unable to provide informed consent
- Patients with QTc >450ms
- Patients with a history of symptomatic congestive heart failure
- Patients with LFT's >3xULN
- Patients who are pregnant
- Patients with a known allergy to itraconazole
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dallas VA Medical Center
Dallas, Texas, United States, 75216
Actively Recruiting
Research Team
D
David Wang, MD, PhD
CONTACT
T
Thai Pham, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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