Actively Recruiting

Phase 3
Age: 12Years - 17Years
All Genders
NCT06307665

Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

Led by AstraZeneca · Updated on 2026-05-01

440

Participants Needed

135

Research Sites

177 weeks

Total Duration

On this page

Sponsors

A

AstraZeneca

Lead Sponsor

P

Parexel

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this study is to compare the effect of budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI), both administered as needed, on the annualized rate of severe asthma exacerbations in adolescents with a documented clinical diagnosis of asthma and at least one severe exacerbation in the prior year.

CONDITIONS

Official Title

Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

Who Can Participate

Age: 12Years - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Confirmed clinical diagnosis of asthma for at least 12 months
  • Receiving stable scheduled asthma maintenance therapy for at least 3 months
  • Using inhaled short-acting b22-agonist (SABA) as needed
  • History of at least one severe asthma exacerbation within 12 months
  • Use of Sponsor-provided albuterol sulfate inhalation aerosol
  • Demonstrate acceptable metered-dose inhaler administration technique without spacers
  • Able to perform reproducible peak expiratory flow measurements
  • Adhere to protocol-specific contraception methods
  • Negative urine pregnancy test for participants of childbearing potential
  • Body mass index (BMI) less than 40 kg/m
  • Capable of giving assent and caregiver capable of giving written informed consent
Not Eligible

You will not qualify if you...

  • Life-threatening asthma with history of intubation, respiratory arrest, or related severe events
  • More than 3 severe asthma exacerbations within 12 months before screening
  • Recent lower respiratory infection or severe asthma exacerbation treated with systemic corticosteroids within 4 weeks
  • Unresolved upper respiratory infection requiring antibiotics
  • Current smokers, former smokers with over 10 pack-years, or quit less than 6 months ago including vaping and marijuana
  • Other significant lung diseases or regular oxygen use
  • Clinically significant diseases including cardiovascular, hepatic, renal, hematological, neuropsychological, endocrine, or gastrointestinal disorders
  • Cancer not in complete remission for at least 5 years
  • Recent hospitalization for psychiatric disorder or suicide attempt within one year
  • Significant alcohol or drug abuse
  • Use of oral corticosteroids within 4 weeks or chronic use in prior 3 months
  • Use of oral short-acting beta-agonists within one month
  • Known or suspected allergy to albuterol, budesonide, or their excipients

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 135 locations

1

Research Site

Anchorage, Alaska, United States, 99508

Actively Recruiting

2

Research Site

Gilbert, Arizona, United States, 85234

Actively Recruiting

3

Research Site

Phoenix, Arizona, United States, 85016

Not Yet Recruiting

4

Research Site

Little Rock, Arkansas, United States, 72202

Completed

5

Research Site

Long Beach, California, United States, 90806

Actively Recruiting

6

Research Site

Long Beach, California, United States, 90815

Actively Recruiting

7

Research Site

Madera, California, United States, 93636

Not Yet Recruiting

8

Research Site

Mission Viejo, California, United States, 92691

Actively Recruiting

9

Research Site

Moreno Valley, California, United States, 92553

Actively Recruiting

10

Research Site

Orange, California, United States, 92868

Actively Recruiting

11

Research Site

Riverside, California, United States, 92506

Actively Recruiting

12

Research Site

San Diego, California, United States, 92123

Actively Recruiting

13

Research Site

San Diego, California, United States, 92123

Not Yet Recruiting

14

Research Site

San Francisco, California, United States, 94143

Withdrawn

15

Research Site

Westminster, California, United States, 92683

Actively Recruiting

16

Research Site

Denver, Colorado, United States, 80206

Actively Recruiting

17

Research Site

Wilmington, Delaware, United States, 19803

Actively Recruiting

18

Research Site

Destin, Florida, United States, 32541

Actively Recruiting

19

Research Site

Jacksonville, Florida, United States, 32207

Actively Recruiting

20

Research Site

Kendall, Florida, United States, 33176

Not Yet Recruiting

21

Research Site

Largo, Florida, United States, 33777

Completed

22

Research Site

Miami, Florida, United States, 33145

Actively Recruiting

23

Research Site

Pembroke Pines, Florida, United States, 33026

Not Yet Recruiting

24

Research Site

Tampa, Florida, United States, 33613

Withdrawn

25

Research Site

Atlanta, Georgia, United States, 30329

Actively Recruiting

26

Research Site

Columbus, Georgia, United States, 31904

Actively Recruiting

27

Research Site

Fayetteville, Georgia, United States, 30214

Actively Recruiting

28

Research Site

Snellville, Georgia, United States, 30078

Not Yet Recruiting

29

Research Site

Meridian, Idaho, United States, 83646

Withdrawn

30

Research Site

Normal, Illinois, United States, 61761

Actively Recruiting

31

Research Site

River Forest, Illinois, United States, 60305

Withdrawn

32

Research Site

Indianapolis, Indiana, United States, 46202

Actively Recruiting

33

Research Site

Kansas City, Kansas, United States, 66160

Actively Recruiting

34

Research Site

Louisville, Kentucky, United States, 40202

Actively Recruiting

35

Research Site

Lafayette, Louisiana, United States, 70508

Actively Recruiting

36

Research Site

New Orleans, Louisiana, United States, 70121

Actively Recruiting

37

Research Site

Ellicott City, Maryland, United States, 21043

Actively Recruiting

38

Research Site

Silver Spring, Maryland, United States, 20902

Actively Recruiting

39

Research Site

White Marsh, Maryland, United States, 21162

Actively Recruiting

40

Research Site

Boston, Massachusetts, United States, 02114

Not Yet Recruiting

41

Research Site

Detroit, Michigan, United States, 48201

Actively Recruiting

42

Research Site

Mankato, Minnesota, United States, 56001

Active, Not Recruiting

43

Research Site

Kansas City, Missouri, United States, 64108

Withdrawn

44

Research Site

Kansas City, Missouri, United States, 64118

Actively Recruiting

45

Research Site

Missoula, Montana, United States, 59804

Actively Recruiting

46

Research Site

Lincoln, Nebraska, United States, 68510

Actively Recruiting

47

Research Site

Lincoln, Nebraska, United States, 68516

Actively Recruiting

48

Research Site

Omaha, Nebraska, United States, 68114

Actively Recruiting

49

Research Site

Newark, New Jersey, United States, 07103

Actively Recruiting

50

Research Site

Northfield, New Jersey, United States, 08225

Actively Recruiting

51

Research Site

Ocean City, New Jersey, United States, 07712

Actively Recruiting

52

Research Site

Paramus, New Jersey, United States, 07652

Actively Recruiting

53

Research Site

Albuquerque, New Mexico, United States, 87106

Actively Recruiting

54

Research Site

Albany, New York, United States, 12208

Actively Recruiting

55

Research Site

Cortland, New York, United States, 13045

Actively Recruiting

56

Research Site

Hawthorne, New York, United States, 10532

Actively Recruiting

57

Research Site

Hollis, New York, United States, 11423

Withdrawn

58

Research Site

New York, New York, United States, 10019

Withdrawn

59

Research Site

New York, New York, United States, 10032

Actively Recruiting

60

Research Site

Rochester, New York, United States, 14607

Completed

61

Research Site

The Bronx, New York, United States, 10459

Actively Recruiting

62

Research Site

The Bronx, New York, United States, 10461

Actively Recruiting

63

Research Site

Vestal, New York, United States, 13850

Actively Recruiting

64

Research Site

Vestal, New York, United States, 13850

Withdrawn

65

Research Site

Watertown, New York, United States, 13601

Actively Recruiting

66

Research Site

Charlotte, North Carolina, United States, 28277

Withdrawn

67

Research Site

Cincinnati, Ohio, United States, 45229

Not Yet Recruiting

68

Research Site

Columbus, Ohio, United States, 43205

Not Yet Recruiting

69

Research Site

Columbus, Ohio, United States, 43228

Not Yet Recruiting

70

Research Site

Dayton, Ohio, United States, 45424

Actively Recruiting

71

Research Site

Findlay, Ohio, United States, 45840

Actively Recruiting

72

Research Site

Toledo, Ohio, United States, 43617

Actively Recruiting

73

Research Site

Oklahoma City, Oklahoma, United States, 73104

Actively Recruiting

74

Research Site

Oklahoma City, Oklahoma, United States, 73120

Actively Recruiting

75

Research Site

Yukon, Oklahoma, United States, 73099

Actively Recruiting

76

Research Site

Pittsburgh, Pennsylvania, United States, 15241

Actively Recruiting

77

Research Site

Charleston, South Carolina, United States, 29425

Actively Recruiting

78

Research Site

Rock Hill, South Carolina, United States, 29730

Active, Not Recruiting

79

Research Site

Sioux Falls, South Dakota, United States, 57105

Actively Recruiting

80

Research Site

Nashville, Tennessee, United States, 37232

Actively Recruiting

81

Research Site

Austin, Texas, United States, 78759

Actively Recruiting

82

Research Site

Baytown, Texas, United States, 77521

Actively Recruiting

83

Research Site

Beaumont, Texas, United States, 77701

Actively Recruiting

84

Research Site

Beaumont, Texas, United States, 77702

Not Yet Recruiting

85

Research Site

Bellaire, Texas, United States, 77401

Actively Recruiting

86

Research Site

Corsicana, Texas, United States, 75110

Actively Recruiting

87

Research Site

Dallas, Texas, United States, 75231

Actively Recruiting

88

Research Site

Frisco, Texas, United States, 75034

Withdrawn

89

Research Site

Houston, Texas, United States, 77065

Actively Recruiting

90

Research Site

Houston, Texas, United States, 77099

Actively Recruiting

91

Research Site

Kerrville, Texas, United States, 78028

Withdrawn

92

Research Site

McKinney, Texas, United States, 75069

Actively Recruiting

93

Research Site

San Antonio, Texas, United States, 78215

Actively Recruiting

94

Research Site

San Antonio, Texas, United States, 78229

Actively Recruiting

95

Research Site

Tyler, Texas, United States, 75708

Completed

96

Research Site

West Jordan, Utah, United States, 84088

Actively Recruiting

97

Research Site

Burlington, Vermont, United States, 05405

Actively Recruiting

98

Research Site

Burke, Virginia, United States, 22015

Withdrawn

99

Research Site

Bellingham, Washington, United States, 98225

Completed

100

Research Site

Vancouver, Washington, United States, 98664

Actively Recruiting

101

Research Site

Beijing, China, 100050

Actively Recruiting

102

Research Site

Beijing, China, 100191

Actively Recruiting

103

Research Site

Bengbu, China, 233004

Actively Recruiting

104

Research Site

Chengdu, China, 610066

Actively Recruiting

105

Research Site

Chongqing, China, 401122

Actively Recruiting

106

Research Site

Hohhot, China, 10050

Actively Recruiting

107

Research Site

Mianyang, China, 621000

Actively Recruiting

108

Research Site

Shanghai, China, 200062

Actively Recruiting

109

Research Site

Shanghai, China, 200433

Actively Recruiting

110

Research Site

Shanghai, China

Actively Recruiting

111

Research Site

Shantou, China, 515041

Actively Recruiting

112

Research Site

Shenyang, China, 110004

Actively Recruiting

113

Research Site

Shenzhen, China, 518026

Actively Recruiting

114

Research Site

Suzhou, China, 215002

Actively Recruiting

115

Research Site

Taizhou, China, 318000

Actively Recruiting

116

Research Site

Tianjin, China, 300050

Actively Recruiting

117

Research Site

Tianjin, China, 300134

Actively Recruiting

118

Research Site

Tianjin, China, 300211

Actively Recruiting

119

Research Site

Wuhan, China, 430000

Actively Recruiting

120

Research Site

Yanji, China, 133000

Actively Recruiting

121

Research Site

Yantai, China, 264000

Actively Recruiting

122

Research Site

Zhongshan, China, 528400

Actively Recruiting

123

Research Site

Chihuahua City, Mexico, 31000

Actively Recruiting

124

Research Site

Chihuahua City, Mexico, 31238

Actively Recruiting

125

Research Site

Guadalajara, Mexico, 44100

Actively Recruiting

126

Research Site

Guadalajara, Mexico, 44500

Actively Recruiting

127

Research Site

Monterrey, Mexico, 64465

Actively Recruiting

128

Research Site

Durban, South Africa, 3630

Actively Recruiting

129

Research Site

Durban, South Africa, 4001

Actively Recruiting

130

Research Site

Durban, South Africa, 4092

Actively Recruiting

131

Research Site

Krugersdorp, South Africa, 1739

Actively Recruiting

132

Research Site

Middelburg, South Africa, 1055

Actively Recruiting

133

Research Site

Panorama, South Africa, 7500

Actively Recruiting

134

Research Site

Somerset West, South Africa, 7130

Not Yet Recruiting

135

Research Site

Welkom, South Africa, 9460

Actively Recruiting

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Research Team

A

AstraZeneca Clinical Study Information Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma | DecenTrialz