Study of Different Therapy Options for Adults With PTSD Who Do Not Respond to Initial Treatment

What this Trial Is About

This research aims to improve treatment options for people with PTSD who did not respond to their first therapy. It evaluates how practical it is to offer another round of proven therapy and compares different therapy options for those who did not improve initially. The goal is to better personalize care by identifying factors that predict treatment response and creating a simple tool to identify non-responders early, helping patients start alternative treatments sooner. All participants begin with 10 sessions of Cognitive Processing Therapy, a behavioral treatment focused on changing unhelpful thinking patterns. One week after completing this therapy, participants with higher PTSD symptom scores will be offered an additional course of treatment, which may include more sessions of Cognitive Processing Therapy, Prolonged Exposure therapy, or Skills Training for Affective and Interpersonal Regulation STAIR. These therapies are also behavioral treatments aimed at reducing distress and improving emotional regulation. Participants will be involved in therapy sessions and will complete self-report and clinician assessments at multiple points during the study. The main outcomes measured include changes in PTSD symptoms from baseline to six months using the PTSD Checklist for DSM-5 and the Clinician Administered PTSD Scale for DSM-5. Researchers will monitor participants progress and symptom changes to evaluate the effectiveness of these therapy options and improve personalized PTSD care. The study is scheduled to continue until June 2030.

Evaluating Evidenced Based Options for PTSD Treatment