Actively Recruiting
Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury
Led by Mansoura University · Updated on 2025-04-02
100
Participants Needed
2
Research Sites
18 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors. The receptor blockade profile of a beta blocker can influence its physiological effects and potential therapeutic benefits in TBI. Therefore, the variation in receptor selectivity may result in differences in their impact on secondary brain injury processes and patient outcomes.
CONDITIONS
Official Title
Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with moderate or severe traumatic brain injury detected by CT scan and Glasgow Coma Scale score of 13 or less
- Patients with no other injuries or only minor associated injuries, including mild intraperitoneal free fluid, mild lung contusion, hemothorax or pneumothorax without symptoms, or simple limb fractures
You will not qualify if you...
- Patients currently on beta blocker therapy before injury
- Patients with bronchospastic lung conditions
- Patients with active acute coronary syndrome
- Patients with traumatic brain injury and major associated injuries requiring surgery or causing severe symptoms, such as moderate or marked intraperitoneal free fluid needing laparotomy, moderate or marked lung contusion or pneumothorax with symptoms, compound limb fractures, or open faciomaxillary trauma
- Patients with persistent shock after more than one week of admission, defined by low blood pressure, high base deficit, low urine output, or low heart rate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Zagazig University Hospitals, Zagazig,
Zagazig, Egypt
Actively Recruiting
2
Zagazig University Hospitals
Zagazig, Egypt
Not Yet Recruiting
Research Team
A
Aya Osama Nagaty
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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