Actively Recruiting
Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation
Led by University Hospital, Gasthuisberg · Updated on 2025-12-09
40
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced. As this study is setup as a pilot study, the main questions it aims to determine the potential impacted parameters as well as their effect sizes, of cryo-analgesia on both short and long term outcomes following bilateral lung transplantation in COPD patients in a European high volume lung transplant centre. The efficacy parameters under evaluation will be: * is the highest pain score affected by the use of cryo nerve block? * Is there an effect on the lung function ? * Does cryo nerve block cause specific complications? * are patients treated with cryo nerve block still needing the same amount of morphine as a pain killer? * is the length of stay in intensive care influenced by the use of cryo nerve block? * and is the qualiy of life influenced by the use of cryo nerve block? Participants will: * undergo cryo nerve block or receive routine pain treatment after bilateral lung transplantation * be followed up during the first week after the operation, and every month to determine their pain * be asked to perform a lung function test and complete quality of life questionnaires 1, 2, 3, 6 months and 1 year after transplantation
CONDITIONS
Official Title
Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntary written informed consent obtained from participant or legal representative before screening
- At least 18 years old at time of consent
- Undergoing bilateral lung transplantation at UZ Leuven
- Diagnosed with end stage chronic obstructive pulmonary disease (COPD) requiring transplantation
- Use of lungs stored on classic ice or cooled systems like LUNGguard4 or X6Port Lung Transport Device allowed
- Previous lung volume reduction or talcage procedures do not exclude participation
You will not qualify if you...
- Unilateral lung transplantation
- Lobar lung transplantation
- Donor lung treated with ex-vivo lung perfusion (EVLP)
- Combined organ transplantation
- Chronic opioid use before surgery
- Participation in other interventional trials with investigational drugs or devices that may affect outcomes
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
Research Team
H
Hans Van Veer, MD
CONTACT
C
Celine Rihon, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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