Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06959056

Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation

Led by University Hospital, Gasthuisberg · Updated on 2025-12-09

40

Participants Needed

1

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced. As this study is setup as a pilot study, the main questions it aims to determine the potential impacted parameters as well as their effect sizes, of cryo-analgesia on both short and long term outcomes following bilateral lung transplantation in COPD patients in a European high volume lung transplant centre. The efficacy parameters under evaluation will be: * is the highest pain score affected by the use of cryo nerve block? * Is there an effect on the lung function ? * Does cryo nerve block cause specific complications? * are patients treated with cryo nerve block still needing the same amount of morphine as a pain killer? * is the length of stay in intensive care influenced by the use of cryo nerve block? * and is the qualiy of life influenced by the use of cryo nerve block? Participants will: * undergo cryo nerve block or receive routine pain treatment after bilateral lung transplantation * be followed up during the first week after the operation, and every month to determine their pain * be asked to perform a lung function test and complete quality of life questionnaires 1, 2, 3, 6 months and 1 year after transplantation

CONDITIONS

Official Title

Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Voluntary written informed consent obtained from participant or legal representative before screening
  • At least 18 years old at time of consent
  • Undergoing bilateral lung transplantation at UZ Leuven
  • Diagnosed with end stage chronic obstructive pulmonary disease (COPD) requiring transplantation
  • Use of lungs stored on classic ice or cooled systems like LUNGguard4 or X6Port Lung Transport Device allowed
  • Previous lung volume reduction or talcage procedures do not exclude participation
Not Eligible

You will not qualify if you...

  • Unilateral lung transplantation
  • Lobar lung transplantation
  • Donor lung treated with ex-vivo lung perfusion (EVLP)
  • Combined organ transplantation
  • Chronic opioid use before surgery
  • Participation in other interventional trials with investigational drugs or devices that may affect outcomes

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

University Hospitals Leuven

Leuven, Vlaams-Brabant, Belgium, 3000

Actively Recruiting

Loading map...

Research Team

H

Hans Van Veer, MD

CONTACT

C

Celine Rihon, RN

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here