Actively Recruiting
Impact of Functional and Cognitive Rehabilitation in Adults With Chronic Noncommunicable Diseases and Long Covid-19 on Their Function, Cognition, Quality of Life, and Disease Progression
Led by Fundación Cardioinfantil Instituto de Cardiología · Updated on 2026-04-13
374
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
F
Fundación Cardioinfantil Instituto de Cardiología
Lead Sponsor
H
Hospital Militar Central, Colombia
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the effects of a functional and cognitive rehabilitation program compared to informational support on adults with chronic non-communicable diseases and Long Covid-19. The study aims to assess changes in functional capacity, cognitive abilities, quality of life, and disease progression. Previous identification of eligible patients was done through institutional registries, with diagnosis based on persistent symptoms that impact daily life and are not explained by other conditions. Participants are randomly assigned to one of two groups for 8 weeks: one group attends weekly in-person sessions involving supervised physical exercises such as warm-up, aerobic activity, muscle strengthening, and cool-down, plus cognitive rehabilitation sessions targeting memory, attention, and executive functions. The other group receives three weekly evidence-based educational messages via email or text covering Covid-19 prevention, treatment, and prognosis. Participants will be evaluated at the start, immediately after the intervention, and six months later through tests including a six-minute walk, handgrip strength, and questionnaires measuring disability, anxiety, depression, fatigue, breathlessness, cognitive function, and quality of life. Trained, blinded assessors conduct evaluations to ensure objectivity. Safety is monitored during exercise sessions, and participants can withdraw at any time without affecting their usual care.
CONDITIONS
Brief Title
Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed Covid-19 diagnosis.
- History of arterial hypertension or diabetes mellitus before Covid-19 infection.
- Persistence of two or more concurrent symptoms related to Covid-19 lasting at least 4 weeks.
- At least one symptom significantly impacts daily activities (physical or neuropsychiatric).
- Symptoms are not explained by other underlying diseases.
- Ability to attend in-person rehabilitation sessions or receive informational messages.
You will not qualify if you...
- Age over 80 years.
- Severely advanced baseline comorbidities before Covid-19 infection.
- Chronic respiratory disease requiring oxygen support.
- Heart failure with left ventricular ejection fraction less than 40%.
- Advanced kidney disease with glomerular filtration rate below 30%.
- Two hospitalizations in the year prior to study enrollment for underlying disease.
- Dependence on a caregiver.
- Orthopedic or cardiopulmonary issues preventing aerobic exercise.
- Neuropsychiatric or cognitive impairments limiting understanding or exercise participation.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - 8 weeks
Participants undergo either a functional and cognitive rehabilitation strategy involving weekly in-person supervised sessions for 8 weeks, or receive weekly evidence-based informational support messages for 8 weeks to improve functional capacity, cognitive function, and quality of life.
Weekly visits for 8 weeks (in-person for rehabilitation group); weekly digital messages for 8 weeks for informational support group
Duration - 6 months
Participants complete assessments to evaluate changes in functional capacity, cognitive function, quality of life, and disease progression after treatment completion, including a post-intervention visit and a six-month follow-up.
2 visits (post-intervention and six-month follow-up, in-person)
Trial Site Locations
Total: 1 location
1
Fundación Cardioinfantil-Instituto de cardiología
Bogotá, Bogotá DC, Colombia, 110131
Actively Recruiting
Research Team
K
Karen J Moreno, PT MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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