Actively Recruiting
Evaluating Modulation Effects of Temporal Interference Using SEEG in Patients with Drug-Resistant Epilepsy
Led by Xuanwu Hospital, Beijing · Updated on 2025-02-05
20
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of temporal interference (TI) stimulation in people aged 14 to 60 who have drug-resistant epilepsy and have implanted intracranial electrodes. This study aims to understand how TI, a new non-invasive deep brain stimulation method, affects brain activity by analyzing clinical, imaging, and electrophysiological data. The goal is to explore TI's potential as an alternative to invasive deep brain stimulation treatments. Participants undergo temporal interference stimulation while being monitored with stereoelectroencephalography (SEEG), which records electrical activity from deep brain structures using implanted electrodes. Researchers observe electrophysiological activity and clinical responses before, during, and after the stimulation to study how TI influences brain function. This process is conducted in a single center and is designed to capture detailed brain activity changes. During the trial, electrophysiological changes are recorded for up to three hours per participant, alongside patients' subjective feelings and symptoms. Data from clinical observations, imaging, and electrophysiology are collected and analyzed to advance knowledge of TI's impact. Participants will be closely monitored throughout the procedure to ensure safety and gather comprehensive information about the stimulation effects.
CONDITIONS
Brief Title
Evaluating Modulation Effects of Temporal Interference Using SEEG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of drug-resistant epilepsy
- No severe systemic diseases
- Implantation of stereotactic electrodes
- Agreement to participate in this study and signs the informed consent form
You will not qualify if you...
- Hematoma at the scalp electrode site or fluid accumulation under the electrode after intracranial electrode placement
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 hours for each participant
Participants undergo temporal interference stimulation while implanted with depth electrodes. Researchers record electrophysiological and clinical data during the stimulation period.
1 in-person visit during which stimulation and data collection occur
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital,Capital Medical University
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
Research Team
L
Liankun Ren, MD
R
Ren, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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