Study of Temporal Interference Effects on Deep Brain Stimulation in Patients with Drug-Resistant Epilepsy Using SEEG

What this Trial Is About

Researchers are studying the effects of temporal interference TI stimulation in people aged 14 to 60 who have drug-resistant epilepsy and have implanted intracranial electrodes. This study aims to understand how TI, a new non-invasive deep brain stimulation method, affects brain activity by analyzing clinical, imaging, and electrophysiological data. The goal is to explore TIs potential as an alternative to invasive deep brain stimulation treatments. Participants undergo temporal interference stimulation while being monitored with stereoelectroencephalography SEEG, which records electrical activity from deep brain structures using implanted electrodes. Researchers observe electrophysiological activity and clinical responses before, during, and after the stimulation to study how TI influences brain function. This process is conducted in a single center and is designed to capture detailed brain activity changes. During the trial, electrophysiological changes are recorded for up to three hours per participant, alongside patients subjective feelings and symptoms. Data from clinical observations, imaging, and electrophysiology are collected and analyzed to advance knowledge of TIs impact. Participants will be closely monitored throughout the procedure to ensure safety and gather comprehensive information about the stimulation effects.

Evaluating Modulation Effects of Temporal Interference Using SEEG