Actively Recruiting
Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy
Led by University Health Network, Toronto · Updated on 2026-03-05
45
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective observational study which aims to identify individuals predisposed to developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) could improve patient outcomes in different ways. First, it will enable improved patient selection for PRRT where alternative treatment options are available. Second, understanding the final pathway and how it is modulated by PRRT could allow the design of strategies to halt this process. Third, while it is unknown whether the development of MDS and AML is a late effect of radiopharmaceuticals in general or it is confined to cancer populations or specific radioisotopes will need to be confirmed. Finally, understanding this devastating complication is expected to be the cornerstone towards advancing radiopharmaceuticals' role in the adjuvant setting.
CONDITIONS
Official Title
Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ECOG performance status 0 to 3
- Life expectancy greater than 6 months
- Provide informed consent and agree to serial genetic panel CHIP testing
- Cohort A: Completed PRRT within 5 years before enrollment
- Cohort B: Planned to start PRRT within 4 months after enrollment
- Cohort C: Diagnosed with MDS or AML after prior PRRT
You will not qualify if you...
- Unwillingness to provide blood samples and attend follow-up as per protocol
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
R
Rebecca Wong
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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