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Comparing Dexmedetomidine and Lignocaine Infusions for Laparoscopic Gallbladder Surgery Effects on Heart Function, Pain Relief, and Gut Recovery
Led by Sahiwal medical college sahiwal · Updated on 2024-12-18
140
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating the effects of dexmedetomidine and lignocaine infusions on patients undergoing laparoscopic cholecystectomy, focusing on perioperative hemodynamics, postoperative pain, and gastrointestinal recovery. This randomized controlled trial compares these two drugs to find evidence regarding their impact on reducing opioid-related side effects and managing pain and hemodynamic responses during and after surgery. The study is conducted at Sahiwal Teaching Hospital over 12 months with 140 patients divided into two groups. Participants will be randomly assigned to receive either dexmedetomidine infusion at 0.2-0.4 gkgh or lignocaine infusion at 1-2 mgkgh during surgery. All patients undergo standardized anesthesia induction and maintenance, including pre-oxygenation, propofol, nalbuphine, succinylcholine, isoflurane, nitrous oxide, oxygen, and atracurium. Intraoperative monitoring includes heart rate, blood pressure, oxygen saturation, end-tidal CO2, and temperature. Rescue treatments for hypotension and bradycardia are provided as needed. Postoperative care includes pain assessment, opioid use tracking, nausea and vomiting monitoring, and evaluation of gastrointestinal function using the I-FEED scale over 24 hours. Participants will be assessed before surgery, during anesthesia, and for 24 hours postoperatively in the intensive care unit. Heart rate and mean arterial pressure are monitored at several time points during surgery. Postoperative pain is measured with a visual analogue scale, and rescue analgesia is given when pain reaches a specific level. Researchers will record total opioid consumption and recovery of gastrointestinal function at 6, 12, and 24 hours after surgery. All data, including demographics and operative details, are collected systematically to evaluate the effects of the two infusions.
CONDITIONS
Brief Title
Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy
Research Team
T
Tallal Shahid, MBBS
D
Dr Muhammad Shahid, FCPS
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