The relationship between falls history and computerized dynamic posturography in persons with balance and vestibular disorders.
Susan L Whitney, Gregory F Marchetti, Annika I Schade
https://pubmed.ncbi.nlm.nih.gov/16500176Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID05702749
Evaluating Pre-Treatment Vestibular Physical Therapy Rehabilitation for Patients with Vestibular Schwannomas Undergoing Surgery or Radiosurgery
Led by Medical College of Wisconsin · Updated on 2026-03-24
36
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of pre-treatment vestibular physical therapy rehabilitation (PREHAB) in patients with Vestibular Schwannomas (VS) who are undergoing either surgery or stereotactic radiosurgery (SRS). This pilot randomized study aims to estimate balance scores before and after treatment to better understand how PREHAB may influence recovery. The study enrolls patients diagnosed with VS who are eligible for either surgical or radiosurgical management. Participants will be randomized into four groups: PREHAB plus surgery, surgery alone, PREHAB plus radiosurgery, and radiosurgery alone. PREHAB involves weekly visits for three weeks before treatment to develop an exercise program including balance exercises twice daily, gaze stabilization exercises for 12 to 20 minutes daily, and habituation exercises as applicable. Surgical approaches include microsurgical resection using various techniques, while radiosurgery is delivered as a single fraction using Gamma Knife or linear accelerator technology. During the study, participants will undergo baseline and multiple post-treatment balance assessments using the Sensory Organization Test at 1 week, 6 weeks, 6 months, and 12 months after treatment. Researchers will monitor participants' adherence to therapy exercises and collect self-reported questionnaires. The total involvement includes initial PREHAB visits (if assigned), treatment procedures, and follow-up balance evaluations over a year to assess outcomes and safety.
CONDITIONS
Brief Title
Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Signed informed consent form
- Male or female participants 18 years of age or older
- Initial diagnosis of Vestibular Schwannoma confirmed by MRI
- Tumor size 2.5 cm or smaller
- Planned treatment with surgery or stereotactic radiosurgery
- ECOG Performance Status less than 2
- Normal laboratory values within 14 days prior to registration, supporting safe treatment
- Willingness to follow study protocol and complete questionnaires
- For females of reproductive potential: negative pregnancy test within 7 days prior to enrollment and agreement to use effective contraception during study and for 24 weeks after radiosurgery
You will not qualify if you...
- Under 18 years of age
- Prior treatment for Vestibular Schwannoma including surgery, radiotherapy, or salvage procedures
- Secondary vestibular diagnoses such as Meniere's disease, intractable benign paroxysmal positional vertigo, vestibular migraine, or 3PD
- Medical conditions significantly affecting balance or vestibular testing, including prior stroke or uncorrected vision impairment
- Planned radiation treatment other than stereotactic radiosurgery
- Inability to safely undergo MRI scans
- Allergy to gadolinium contrast used in MRI
- Pregnant women or females unwilling to use contraception during study and 24 weeks post radiosurgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Run-in Period
Duration - 3 weeks
Participants in the PREHAB groups attend weekly physical therapy visits to determine a personalized exercise regimen including balance, gaze stabilization, and habituation exercises to be done daily before surgery or radiosurgery.
3 weekly visits (in-person)
Treatment
Duration - Single day for surgery or radiosurgery
Participants undergo either microsurgical resection of vestibular schwannoma or stereotactic radiosurgery as determined by clinical consultation and randomization.
1 treatment visit (in-person)
Post-treatment Follow-up
Duration - 12 months
Participants are assessed to monitor recovery and sensory organization at multiple time points after treatment.
4 follow-up visits at 1 week, 6 weeks, 6 months, and 12 months post-treatment
Trial Site Locations
Total: 1 location
1
Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
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Research Team
M
Medical College of Wisconsin Cancer Center Clinical Trials Office
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
4
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Published Research Related To This Trial
Learning effects of repetitive administrations of the sensory organization test in healthy young adults.
Diane M Wrisley, Marilee J Stephens, Shaun Mosley...
https://pubmed.ncbi.nlm.nih.gov/17678669Vestibular Rehabilitation for Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From the Academy of Neurologic Physical Therapy of the American Physical Therapy Association.
Courtney D Hall, Susan J Herdman, Susan L Whitney...
https://pubmed.ncbi.nlm.nih.gov/34864777