Pilot Study of Pre-Treatment Vestibular Physical Therapy for Adults with Vestibular Schwannoma Undergoing Surgery or Radiosurgery
Led by Medical College of Wisconsin · Updated on 2026-03-24
36
Participants Needed
1
Research Sites
21 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of pre-treatment vestibular physical therapy rehabilitation PREHAB in patients with Vestibular Schwannomas VS who are undergoing either surgery or stereotactic radiosurgery SRS. This pilot randomized study aims to estimate balance scores before and after treatment to better understand how PREHAB may influence recovery. The study enrolls patients diagnosed with VS who are eligible for either surgical or radiosurgical management.
Participants will be randomized into four groups PREHAB plus surgery, surgery alone, PREHAB plus radiosurgery, and radiosurgery alone. PREHAB involves weekly visits for three weeks before treatment to develop an exercise program including balance exercises twice daily, gaze stabilization exercises for 12 to 20 minutes daily, and habituation exercises as applicable. Surgical approaches include microsurgical resection using various techniques, while radiosurgery is delivered as a single fraction using Gamma Knife or linear accelerator technology.
During the study, participants will undergo baseline and multiple post-treatment balance assessments using the Sensory Organization Test at 1 week, 6 weeks, 6 months, and 12 months after treatment. Researchers will monitor participants adherence to therapy exercises and collect self-reported questionnaires. The total involvement includes initial PREHAB visits if assigned, treatment procedures, and follow-up balance evaluations over a year to assess outcomes and safety.
CONDITIONS
Brief Title
Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas
Research Team
M
Medical College of Wisconsin Cancer Center Clinical Trials Office
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This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
Factors
PREHAB (vestibular physical therapy) with surgery or stereotactic radiosurgery
Surgery or stereotactic radiosurgery without pre-treatment vestibular physical therapy
What it is
A combined approach involving three weekly sessions of supervised vestibular physical therapy exercises before either microsurgical resection or stereotactic radiosurgery for vestibular schwannoma.
Standard treatment with surgery or stereotactic radiosurgery for vestibular schwannoma, without any dedicated pre-treatment vestibular rehabilitation.
Role in trial
Investigational arm assessing the effect of pre-treatment vestibular rehabilitation on functional and balance outcomes.
Serves as the usual care/control arm receiving only standard intervention without PREHAB.
Primary use or goal
Enhance functional outcomes, particularly balance, by preparing patients for surgery or radiosurgery with vestibular exercise prior to definitive intervention.
Deliver definitive tumor treatment (surgery or SRS) without formal preparatory vestibular physical therapy.
How it is given or performed
Participants complete one weekly supervised PREHAB visit for 3 weeks, consisting of individualized exercise planning, and conduct home-based balance, gaze stabilization, and habituation exercises twice daily and as prescribed prior to surgery/SRS.
Participants proceed directly to surgery or stereotactic radiosurgery without a dedicated pre-treatment rehabilitation program.
Evidence status
High-quality evidence supports vestibular physical therapy for peripheral vestibular dysfunction; the effect of pre-treatment rehabilitation prior to vestibular schwannoma surgery or SRS is under active study and not yet established.
Standard definitive interventions address the tumor, but patients may experience vestibular dysfunction post-treatment; formal pre-treatment rehabilitation is not established as routine care.
Important limitations
The added benefit of pre-treatment vestibular rehab in patients with vestibular schwannoma undergoing surgery or SRS is not yet proven; individual adherence to exercises and baseline functional status may influence outcomes.
Patients may be at risk of ongoing balance issues or falls post-treatment if formal rehabilitation is not provided; usual care may not actively prepare patients for post-intervention vestibular dysfunction.
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
Signed informed consent form
Male or female participants 18 years of age or older
Initial diagnosis of Vestibular Schwannoma confirmed by MRI
Tumor size 2.5 cm or smaller
Planned treatment with surgery or stereotactic radiosurgery
ECOG Performance Status less than 2
Normal laboratory values within 14 days prior to registration, supporting safe treatment
Willingness to follow study protocol and complete questionnaires
For females of reproductive potential: negative pregnancy test within 7 days prior to enrollment and agreement to use effective contraception during study and for 24 weeks after radiosurgery
You will not qualify if you...
Under 18 years of age
Prior treatment for Vestibular Schwannoma including surgery, radiotherapy, or salvage procedures
Secondary vestibular diagnoses such as Meniere's disease, intractable benign paroxysmal positional vertigo, vestibular migraine, or 3PD
Medical conditions significantly affecting balance or vestibular testing, including prior stroke or uncorrected vision impairment
Planned radiation treatment other than stereotactic radiosurgery
Inability to safely undergo MRI scans
Allergy to gadolinium contrast used in MRI
Pregnant women or females unwilling to use contraception during study and 24 weeks post radiosurgery
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Run-in Period
Duration - 3 weeks
Participants in the PREHAB groups attend weekly physical therapy visits to determine a personalized exercise regimen including balance, gaze stabilization, and habituation exercises to be done daily before surgery or radiosurgery.
3 weekly visits (in-person)
Treatment
Duration - Single day for surgery or radiosurgery
Participants undergo either microsurgical resection of vestibular schwannoma or stereotactic radiosurgery as determined by clinical consultation and randomization.
1 treatment visit (in-person)
Post-treatment Follow-up
Duration - 12 months
Participants are assessed to monitor recovery and sensory organization at multiple time points after treatment.
4 follow-up visits at 1 week, 6 weeks, 6 months, and 12 months post-treatment
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
4
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Published Research Related To This Trial
Vestibular Rehabilitation for Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From the Academy of Neurologic Physical Therapy of the American Physical Therapy Association.
Courtney D Hall, Susan J Herdman, Susan L Whitney...