Actively Recruiting
Evaluating Presbyopia-Correcting IOLs in Complex Cataract Cases With Anterior Segment Abnormalities
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-01-07
320
Participants Needed
1
Research Sites
215 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of cataract surgery has evolved from simply restoring sight to providing clear and comfortable full-range vision. Traditionally, monofocal IOLs remain the routine choice for special cases with anterior segment abnormalities-such as lens subluxation, cataract with chronic uveitis, post-laser refractive cataract, and aphakia with insufficient capsular support. However, there is a growing demand among these patients for improved visual quality and spectacle independence.Currently, various presbyopia-correcting IOLs offer distinct advantages, providing more personalized options. The introduction and application of intraoperative optical coherence tomography (iOCT) ensures effective intraoperative monitoring. These advances make the precise implantation of presbyopia-correcting IOLs a promising extension to phacoemulsification in complex cataracts with anterior segment abnormalities. Nevertheless, their exact benefits regarding visual quality, safety, and patient satisfaction require systematic evaluation through rigorous prospective studies and long-term follow-up. Under strict perioperative management, this study will employ iOCT to monitor the accurate implantation of presbyopia-correcting IOLs and will assess postoperative visual quality and patient satisfaction.
CONDITIONS
Official Title
Evaluating Presbyopia-Correcting IOLs in Complex Cataract Cases With Anterior Segment Abnormalities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years with lens subluxation, inactive long-standing anterior uveitis with cataract, post-myopic laser corneal surgery with cataract, or aphakia with insufficient capsular support
- Diagnosed condition meets surgical indications for lens surgery
- Unilateral implantation planned
- Informed consent provided
- Ability to comply with full follow-up visits
- Kappa angle less than 0.5 mm
- Total higher-order aberration root mean square (HOA RMS) within central 4-mm corneal zone less than 1 bcm
- Mesopic natural pupil diameter between 2.5 mm and 5.5 mm depending on group
- Expected postoperative astigmatism less than or equal to 1.0 diopters
- Target spherical equivalent between 0.00 D and �b10.75 D
- Subjective desire to improve full-range visual function
You will not qualify if you...
- Coexisting ocular developmental anomalies such as microphthalmos or microcornea
- Severe or progressive ocular diseases including glaucoma, diabetic retinopathy, macular degeneration, or severe optic nerve disorders
- Other organic ocular pathologies such as pathologic high myopia with fundus changes, significant pupillary abnormalities, severe corneal disease or scarring, high irregular astigmatism, chronic or active uveitis, severe amblyopia
- Lens disorders other than subluxation and cataract
- Intraoperative complications affecting IOL position or outcome such as posterior capsule rupture or iris prolapse
- History of prior ocular surgery including corneal refractive laser surgery, glaucoma surgery, vitrectomy, or posterior vitrectomy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
W
Wen Xu, Phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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