Actively Recruiting

Phase 3
Age: 18Years - 65Years
All Genders
NCT06861010

Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Led by Tanta University · Updated on 2026-03-13

44

Participants Needed

1

Research Sites

94 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Endoscopic retrograde cholangiopancreatography (ERCP (, a key tool that is used in diagnosis and treatment of pancreato-biliary diseases. Post-ERCP pancreatitis (PEP) is the most common and serious complication that can occur following this procedure and can lead to significant morbidity and mortality. A variety of patient-related and procedure-related factors have been associated with higher rates of PEP.

CONDITIONS

Official Title

Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age more than 18 years old.
  • Males and Females
  • Patients with suitable indications for ERCP due to suspected pancreato-biliary disorders.
  • Blood amylase and lipase levels before ERCP are within the normal limits.
Not Eligible

You will not qualify if you...

  • Age of less than 18 years.
  • Uncontrolled diabetes mellitus.
  • Severe bleeding tendency.
  • Impaired renal function (serum creatinine > 2 mg/dL or creatinine clearance <30 ml/min).
  • Severe heart disease.
  • Prior biliary or pancreatic sphincterotomy, dilatation, or stenting of either duct.
  • Currently pregnant or nursing.
  • Admission due to established pancreatitis before ERCP.
  • Unwillingness to undergo ERCP.
  • Previously documented allergy to ondansetron.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Tanta Unuversity

Tanta, Egypt, 31527

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis | DecenTrialz