Actively Recruiting
Evaluating Smoking Cessation Interventions for PWH in South Africa
Led by Johns Hopkins University · Updated on 2025-06-27
660
Participants Needed
1
Research Sites
196 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
C
Colorado State University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.
CONDITIONS
Official Title
Evaluating Smoking Cessation Interventions for PWH in South Africa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Attend one of the selected study clinics
- Have a confirmed HIV diagnosis with evidence such as ART prescription or current ART medication pack
- Have been taking antiretroviral therapy for at least three consecutive months
- Are current tobacco smokers who have smoked at least 100 cigarettes in their lifetime, smoke daily for the past 30 days, have exhaled breath carbon monoxide of 7 ppm or more, and a positive urine cotinine test
- Own or have household access to a mobile phone
- Provide written informed consent
You will not qualify if you...
- Currently receiving smoking cessation counseling or medication within the past 14 days
- Unable to participate due to severe medical illness (Karnofsky score 40 or less)
- History of seizures, cancer, heart disease, stroke, myocardial infarction, stomach ulcers, kidney failure, or liver failure
- Have generalized eczema or psoriasis
- Cognitive dysfunction or psychosis as defined by the Mini-International Neuropsychiatric Interview
- Suicide risk as defined by the Columbia-Suicide Severity Rating Scale
- Pregnant, planning pregnancy within 4 months, lactating, or unwilling to use effective birth control
- History of adverse reactions to varenicline or nicotine patches
- Not planning to continue care at the clinic for the next 52 weeks
- Deemed unsuitable by the attending investigator for the clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Perinatal HIV Research Unit (PHRU)
Soweto, Gauteng, South Africa
Actively Recruiting
Research Team
J
Jonathan E Golub, PhD MPH
CONTACT
L
Laura Steiner, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
16
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