Actively Recruiting
Evaluating Treatable Traits Across the Spectrum of Chronic Obstructive Airways Disease
Led by University of Leeds · Updated on 2025-03-30
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Leeds
Lead Sponsor
T
The Leeds Teaching Hospitals NHS Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Respiratory diseases affect one in five people worldwide and are a leading cause of illness and death. This study focuses on chronic obstructive airways diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, cystic fibrosis, and primary ciliary dyskinesia. Researchers aim to compare lung function and other disease effects across these conditions and explore how specific treatable traits relate to physical activity and quality of life. Participants will undergo pulmonary function testing to assess large and small airway involvement, exercise capacity, physical activity, and body composition. The study includes people with different airway diseases as well as healthy controls. The study is observational and does not involve treatment but collects detailed physiological and health data. During the study, participants' physical activity will be monitored over a 7-day period as the primary outcome. Assessments include lung function tests and exercise evaluations, along with measurements of body composition. Researchers will also collect information on health-related quality of life and other disease-specific traits. The study is led by the University of Leeds and includes adults aged 18 to 65 years.
CONDITIONS
Brief Title
Evaluating Treatable Traits Across the Spectrum of Chronic Obstructive Airways Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prior diagnosis of airways disease following European Respiratory Society guidelines
- Non-smokers or ex-smokers (smoking history recorded)
- Male or female aged 18 to 65 years
- Ability to provide written informed consent
- Full understanding of spoken and written English
- Cystic Fibrosis patients on triple CFTR modulators (90% of cohort)
- Cystic Fibrosis patients not on CFTR modulators
- Healthy controls with no respiratory symptoms or inhaler use history
You will not qualify if you...
- Severe exacerbation needing hospital admission or oral corticosteroids in past 2 months
- Contraindications to cardio-pulmonary or submaximal exercise testing
- Contraindications to pulmonary function testing
- Contraindications to dual energy x-ray (DEXA) scanning such as pregnancy or recent contrast media
- Non-ambulant or musculoskeletal issues affecting daily activities or exercise
- Significant cognitive impairment preventing consent or test participation
- Currently receiving oxygen therapy
- Unable to provide consent
- Infection with Burkholderia Cepacia Complex, mycobacterium tuberculosis, or mycobacterium abseccus
- History of lung transplantation
- Diagnosis of cardiovascular disease
- Abnormal blood tests such as anemia or moderate/severe renal failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo pulmonary function testing to assess lung function, exercise capacity, physical activity, and body composition.
1 visit (in-person)
Duration - 7 days
Participants' physical activity is monitored over a 7 day period.
Continuous monitoring during this period
Trial Site Locations
Total: 1 location
1
University of Leeds
Leeds, Leeds, United Kingdom, LS2 9JT
Actively Recruiting
Research Team
O
Oliver Price, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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