Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05974631

Evaluating Treatments for Suicidal Veterans With PTSD

Led by VA Office of Research and Development · Updated on 2025-12-23

125

Participants Needed

4

Research Sites

164 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Posttraumatic Stress Disorder (PTSD) is a significant driver of suicide risk among Veterans, but there is a critical knowledge gap about how to treat PTSD among people at elevated risk for suicide. Although evidence-based treatments for PTSD reduce suicide risk, Veterans at high risk for suicidal behavior rarely receive these potentially life-saving treatments. Prior research suggests that a treatment that combines Dialectical Behavior Therapy (DBT) with the DBT Prolonged Exposure protocol (DBT PE) for PTSD improves both PTSD and suicide-related outcomes. This study will evaluate whether DBT + DBT PE improves these outcomes more than Prolonged Exposure plus suicide risk management, the gold standard VA care for this population. The proposed study will also examine factors that make it easier and harder to implement these treatments in VA settings. The results will help to inform treatment guidelines for this high-priority Veteran population.

CONDITIONS

Official Title

Evaluating Treatments for Suicidal Veterans With PTSD

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • PTSD diagnosis
  • Recent and repeated self-directed violence
  • Current suicidal ideation
  • Emotion dysregulation
  • Veteran eligible for VA mental health care at participating site
  • Age 18 years or older
  • Willing to participate in all study activities
Not Eligible

You will not qualify if you...

  • Unable to maintain safety independently
  • Currently engaged in or recent history (past year) of sufficient Dialectical Behavior Therapy or Prolonged Exposure therapy
  • Plan to move away or be unavailable for more than 4 weeks in the next 18 months
  • Unable to understand study procedures due to limited English proficiency or moderate to severe cognitive impairment

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 4 locations

1

Minneapolis VA Health Care System, Minneapolis, MN

Minneapolis, Minnesota, United States, 55417-2309

Actively Recruiting

2

Durham VA Medical Center, Durham, NC

Durham, North Carolina, United States, 27705-3875

Actively Recruiting

3

South Texas Health Care System, San Antonio, TX

San Antonio, Texas, United States, 78229-4404

Actively Recruiting

4

VA Puget Sound Health Care System Seattle Division, Seattle, WA

Seattle, Washington, United States, 98108-1532

Actively Recruiting

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Research Team

M

Melanie S Harned, PhD

CONTACT

J

John C Fortney, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Evaluating Treatments for Suicidal Veterans With PTSD | DecenTrialz