Actively Recruiting
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA
Led by Virginia Commonwealth University · Updated on 2026-02-17
50
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
Sponsors
V
Virginia Commonwealth University
Lead Sponsor
T
Thermo Fisher Scientific, Inc
Collaborating Sponsor
AI-Summary
What this Trial Is About
Kidney transplant rejection remains a significant challenge to long-term graft survival. While histological biopsy continues to be the gold standard for diagnosing rejection, noninvasive biomarkers such as donor-derived cell-free DNA (dd-cfDNA) have gained traction for their ability to detect allograft injury. However, dd-cfDNA may lack sensitivity in certain clinical scenarios particularly in cases of localized immune activation leading to false negatives despite biopsy-confirmed rejection.
CONDITIONS
Official Title
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Undergoing a clinically indicated biopsy
- Able to provide informed consent
- Willing to provide a urine sample and allow access to relevant clinical data
- Biopsy-confirmed rejection with positive histology (retrospective cohort)
- Donor-derived cell-free DNA less than 1% at time of biopsy (retrospective cohort)
- Availability of stored urine sample collected at time of biopsy (retrospective cohort)
You will not qualify if you...
- Under 18 years of age
- Unable to provide informed consent (for prospective enrollment)
- Pregnant women
- Prisoners
- Adults unable to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
A
Amber Paulus, PhD
CONTACT
G
Gelila Abebe
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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