Actively Recruiting
Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study
Led by ART Fertility Clinics LLC · Updated on 2025-10-02
100
Participants Needed
1
Research Sites
67 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In assisted reproductive technology (ART), sperm preparation aims to select the most viable sperm for ICSI. Unlike conventional methods like density gradients or sperm washing, microfluidic techniques mimic natural selection in the female reproductive tract by using laminar flow without centrifugation, reducing the risk of DNA damage. This method isolates highly motile sperm while filtering out debris and immotile cells. Studies show that microfluidics improve embryo quality, increase pregnancy rates, and may lead to higher euploidy rates. Additional benefits include improved safety, scalability, and shorter preparation times.
CONDITIONS
Official Title
Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with at least 8 MII per cycle after denudation (AFC≥8).
- Women of all ages.
- All embryo qualities ≥BL3CC at the time of biopsy on day 5, 6 and/or 7.
- Fresh sperm used from ejaculate with a concentration ≥1 mill/ml and ≥10% motility (A+B).
- Sperm samples with a minimum of 2 ml.
You will not qualify if you...
- Frozen oocytes samples with severe oligospermia (≤1mill/ml).
- PGT-M cases
- Sperm with > 1M/ml of round cells
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates, 60202
Actively Recruiting
Research Team
J
Jonalyn Edades, Research Coordinator
CONTACT
B
Barbara Lawrenz, Research Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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