Actively Recruiting
Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes
Led by Elizabeth Pfoh · Updated on 2026-01-08
4
Participants Needed
2
Research Sites
89 weeks
Total Duration
On this page
Sponsors
E
Elizabeth Pfoh
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The vast majority of the 36.2 million individuals admitted to U.S. hospitals are diagnosed with hypertension and experience an elevated blood pressure (BP) reading during hospitalization. There are no guidelines for managing asymptomatically elevated BPs in the inpatient setting, and growing observational evidence suggests that antihypertensive medication intensification increases harm. The proposed study tests whether a unit-based intervention (ACT-BP) can reduce antihypertensive medication intensification and provides information that is scientifically necessary for designing a cluster-randomized clinical trial that identifies the impact of intensification after experiencing an asymptomatically elevated BP on patient outcomes.
CONDITIONS
Official Title
Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Medical units that do not typically care for patients requiring step-down care
You will not qualify if you...
- Patients less than 18 years old
- Patients experiencing hypertensive emergencies or cardiac symptoms
- Patients with active cardiovascular events such as stroke, non-ST-elevation myocardial infarction, end-stage renal disease, dialysis, or acute decompensated heart failure
- Patients on the unit for more than 10 days
- Patients transferred in after being in the intensive care unit (ICU)
- Pregnant and post-partum women
- Patients discharged within 24 hours of admission
- Patients whose systolic blood pressure remains below 160 mmHg during hospitalization
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Cleveland Clinic Main Campus
Cleveland, Ohio, United States, 44195
Actively Recruiting
2
Cleveland Clinic Hillcrest
Mayfield Heights, Ohio, United States, 44124
Actively Recruiting
Research Team
E
Elizabeth Pfoh, PhD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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