Actively Recruiting
Evaluating XPERIENCE™ Advanced Surgical Irrigation
Led by Ottawa Hospital Research Institute · Updated on 2025-08-13
7600
Participants Needed
9
Research Sites
247 weeks
Total Duration
On this page
Sponsors
O
Ottawa Hospital Research Institute
Lead Sponsor
N
Next Science TM
Collaborating Sponsor
AI-Summary
What this Trial Is About
A prospective, multi-center, double-arm, parallel, interventional, randomized, controlled clinical trial to assess the rate of periprosthetic joint infection (PJI) in patients undergoing primary total knee arthroplasty (TKA), total hip arthroplasty (THA) or hip resurfacing (HR) with XPERIENCE™ (XP) Advanced Surgical Irrigation versus dilute Betadine (DB).
CONDITIONS
Official Title
Evaluating XPERIENCE™ Advanced Surgical Irrigation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients aged 18 years or older
- Diagnosis of osteoarthritis, inflammatory arthritis, osteonecrosis, or post-traumatic arthritis to the affected joint
- Undergoing primary total knee arthroplasty, total hip arthroplasty, or hip resurfacing
- Receiving either cemented or uncemented orthopedic implants
- Willing and able to sign written consent, follow the study protocol, and attend follow-up visits
You will not qualify if you...
- Unable or unwilling to sign informed consent
- Non-English or French speaking without a licensed translator, family member, or substitute decision maker available
- Previous arthroplasty procedure on the affected joint
- Procedures involving solid hydroxyapatite implants
- Oncologic diagnosis related to the affected joint
- Use of non-TKA, THA, or HR prosthesis (e.g., hemiarthroplasty, unicompartmental arthroplasty)
- Allergy to any component of XPERIENCE Advanced Surgical Irrigation
- Allergy to iodine
- Presence of active infection, primary immunodeficiency, uncontrolled HIV (CD4 <200 cells/uL), immunomodulatory treatment for malignancy or autoimmune disease (except inflammatory arthritis), chronic glucocorticosteroid use (≥20 mg prednisone daily for at least 1 month with another cause of immunosuppression), or solid organ/bone marrow transplantation
- History of septic arthritis in the affected joint within two years before surgery
- History of steroid injection in the affected joint within three months before surgery
- Undergoing simultaneous bilateral total joint arthroplasty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
University of British Columbia
Vancouver, British Columbia, Canada
Not Yet Recruiting
2
London Health Sciences Center
London, Ontario, Canada
Actively Recruiting
3
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
4
Humber River Health
Toronto, Ontario, Canada
Not Yet Recruiting
5
St. Joseph's Health Centre
Toronto, Ontario, Canada
Actively Recruiting
6
Hôpital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Not Yet Recruiting
7
Jewish General Hospital
Montreal, Quebec, Canada
Not Yet Recruiting
8
McGill University
Montreal, Quebec, Canada
Not Yet Recruiting
9
CHU de Quebec-Université Laval
Québec, Quebec, Canada
Not Yet Recruiting
Research Team
S
Sanjula Costa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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