Actively Recruiting
Evaluation of 18F-TFB PET/CT Scan in Patients With Differentiated Thyroid Cancer
Led by Mayo Clinic · Updated on 2026-02-27
24
Participants Needed
1
Research Sites
314 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II study evaluates F-18 tetrafluoroborate (18F-TFB) PET/CT scan in patients with differentiated thyroid cancer. Diagnostic imaging is necessary for planning treatment, monitoring therapy response, and identifying sites of recurrent or metastatic disease in differentiated thyroid cancer. 18F-TFB PET/CT may accurately detect recurrent and metastatic thyroid cancer lesions, with the potential to provide information for patient management that is better than the current standard of care imaging practices.
CONDITIONS
Official Title
Evaluation of 18F-TFB PET/CT Scan in Patients With Differentiated Thyroid Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy-proven papillary or follicular thyroid cancer
- Clinically indicated for 123I-SPECT/CT total body iodine scan
- Agree to undergo 18F-TFB PET/CT scan after TBI scan
- Karnofsky performance status of 50 or higher (or equivalent ECOG/WHO status)
- Able to lie still on SPECT/CT and PET/CT scanner table for up to 65 minutes
- Age 18 years or older
- Able to understand and willing to sign informed consent
- Not pregnant
You will not qualify if you...
- Contrast-enhanced CT within the last 4 weeks
- Use of amiodarone within the last 4 months
- Ingested iodine, kelp tablets, Lugols iodine, or potassium iodide within 2 weeks
- Unable to lie flat, still, or tolerate a PET scan
- Applied betadine, iodoform, or quick tanning products to skin within last 2 weeks
- If using medication withdrawal for stimulation, thyroid stimulating hormone level less than 25
- Taken anti-thyroid medication within 1 week
- Breastfeeding
- Positive pregnancy test
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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