Actively Recruiting
Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Led by Yale University · Updated on 2026-04-06
32
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.
CONDITIONS
Official Title
Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give voluntary written informed consent
- Able to read, write, and communicate effectively with the investigator
- Male or female aged 18 to 60 years at screening
- In good general health based on medical history, physical exam, ECG, serum/urine biochemistry, hematology, and serology tests
- Females of childbearing potential and male subjects must agree to use birth control during the study unless permanently sterile with medical proof
You will not qualify if you...
- Under 18 years of age
- Pregnant or breastfeeding
- Have any significant systemic illness or unstable medical condition
- Have pre-existing medical conditions or claustrophobia
- Have had research-related radiation exposure exceeding PET center guidelines
- Have a history of bleeding disorders or currently take anticoagulants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale University PET Center
New Haven, Connecticut, United States, 06519
Actively Recruiting
Research Team
S
Shannan Henry
CONTACT
K
Kayla R Cottiers
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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