Study Comparing 3D Magnetic Resonance Spirometry With Traditional Spirometry in Healthy Adults and Patients with Asthma, COPD, or Lung Transplants

What this Trial Is About

Researchers are evaluating a new technique called 3D magnetic resonance spirometry to measure lung function in healthy people and patients with respiratory diseases like asthma, COPD, and bilateral lung transplants. This method aims to provide detailed local maps of lung ventilation and mechanics, improving diagnosis beyond traditional spirometry, which only measures global lung function. The study compares results from 3D spirometry with standard spirometry to assess their agreement in four groups healthy volunteers, asthma patients, COPD patients, and lung transplant patients with or without bronchiolitis obliterans syndrome BOS. Participants will undergo several tests, including standard spirometry performed in sitting and lying positions with various breathing types, and dynamic lung MRI scans in prone and supine positions before and after a bronchodilator salbutamol reversibility test. The salbutamol is given via inhalation at a total dose of 400 micrograms. These procedures aim to map lung function regionally and evaluate responses to treatment. During the study, participants will be assessed through lung function tests, MRI scans, and reversibility testing. Researchers will measure lung volumes and airflow differences between lung regions and assess correlations between spontaneous and forced breathing volumes. The study includes monitoring breathing patterns and evaluating lung mechanical behavior. Participants need to remain still during MRI scans and provide informed consent. The total study duration and follow-up details are not specified.

Evaluation of 3D Magnetic Resonance Spirometry: Comparison with Spirometry in Healthy Subjects and Patients with Respiratory Pathologies (asthma, COPD, Bilateral Lung Transplant)