Actively Recruiting

Age: 18Years +
All Genders
ID07584577

Evaluation of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in Esophageal or Stomach Cancer

Led by University Hospital, Bordeaux · Updated on 2026-05-13

670

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

U

University Hospital, Bordeaux

Lead Sponsor

F

French Eso-Gastric Tumors Working Group

Collaborating Sponsor

AI-Summary

What this Trial Is About

Malnutrition is commonly seen in patients diagnosed with esophageal or stomach cancers, affecting 65-80% of cases. It is linked to higher risks such as increased mortality, more postoperative complications, greater toxicity from chemoradiotherapy, and lower survival rates. Malnutrition may worsen during neoadjuvant treatment due to side effects like diarrhea and taste changes. There is currently no clear guidance on the type or duration of nutritional support during this treatment phase, and its impact on postoperative outcomes remains unclear. This observational study compares patients who receive enteral or parenteral nutrition through feeding jejunostomy during neoadjuvant treatment to those who do not receive such nutritional support. The goal is to evaluate how this perioperative nutritional support affects the rate of postoperative complications. Patients are grouped based on whether they received artificial nutrition during their treatment. The study focuses on assessing the presence and extent of postoperative complications within 30 days after surgery. Participants will undergo surgery for esophageal cancer while being monitored for their nutritional status before and during treatment. Researchers will track postoperative complications using the Clavien classification system at 30 days post-surgery. The study involves observing outcomes related to nutrition and surgical recovery without altering standard care. Participants' health status and treatment responses will be evaluated throughout the study period to better understand how nutritional support influences surgical outcomes.

CONDITIONS

Brief Title

Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient undergoing surgery for esophageal cancer
  • Malnourished patient at the time of management
  • Receiving neoadjuvant treatment
Not Eligible

You will not qualify if you...

  • Patient not malnourished at the time of management
  • Patient who did not receive neoadjuvant treatment

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Duration of neoadjuvant treatment

Participants who undergo routine care are observed during neoadjuvant treatment, with or without enteral or parenteral nutrition.

Visits as part of routine clinical care

Surgery and Immediate Post-operative Care

Duration - Up to 30 days post-surgery

Participants undergo surgery for esophageal or stomach cancer followed by immediate post-operative care.

Approximately 1 to 2 visits during hospitalization and early recovery

Trial Site Locations

Total: 1 location

1

Hopîtal du Haut Lévêque

Pessac, France, 33600

Actively Recruiting

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Research Team

C

Caroline GRONNIER, PhD, MD

V

Valérie AURILLAC

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Surgery in esophageal and gastric cancer patients: what is the role for nutrition support in your daily practice?

Christophe Mariette, Marie-Laure De Botton, Guillaume Piessen

https://pubmed.ncbi.nlm.nih.gov/22322948

A systematic review of the effect of preoperative nutrition support on nutritional status and treatment outcomes in upper gastrointestinal cancer resection.

Irene Deftereos, Nicole Kiss, Elizabeth Isenring...

https://pubmed.ncbi.nlm.nih.gov/32336624

Preoperative Nutrition Intervention in Patients Undergoing Resection for Upper Gastrointestinal Cancer: Results from the Multi-Centre NOURISH Point Prevalence Study.

Irene Deftereos, Justin M-C Yeung, Janan Arslan...

https://pubmed.ncbi.nlm.nih.gov/34579082