Actively Recruiting
Evaluation of Antimicrobial Potency of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpectomy of Primary Teeth (Randomized Clinical Trial)
Led by Cairo University · Updated on 2024-08-22
26
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the effectiveness of cinnamon extract versus sodium hypochlorite as root canal irrigants during pulpectomy procedures in primary teeth with irreversible pulpitis. The study focuses on reducing bacterial count since primary teeth with non-vital pulp often contain multiple types of bacteria, including anaerobes, making treatment challenging. Researchers are exploring natural alternatives like cinnamon due to concerns about side effects and safety of synthetic irrigants. Participants will undergo a standardized pulpectomy where infected pulp tissue is removed mechanically using rotary files after estimating root canal length with an apex locator. Two groups will be compared: one receiving sodium hypochlorite irrigation and the other receiving cinnamon extract irrigation prepared from cinnamon bark. Microbial samples are collected before and after irrigation to assess bacterial reduction. Children aged 4 to 8 years with carious primary molars requiring pulpectomy will be involved. The study includes collection of microbial samples, assessment of bacterial colonies, and evaluation of post-operative pain at multiple time points up to 72 hours. All microbiological analysis is conducted in a specialized department. Participants will be monitored for changes in bacterial count on day 1 and pain levels over 3 days following treatment.
CONDITIONS
Brief Title
Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpectomy of Primary Teeth
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 4 to 8 years, in good general health and medically free
- Cooperative patients able to comply with dental treatment
- Parents have provided written informed consent
- No antibiotics taken within the last 2 weeks
- Carious primary molars with irreversible pulpitis
- Teeth showing localized swelling, sinus, or pain on percussion indicating non-vital pulp
- Presence of periapical and furcation radiolucency
- Teeth with no more than one-third root resorption on radiograph
You will not qualify if you...
- Children with medical, physical, or mental conditions
- Severely uncooperative children
- Primary molars with congenital anomalies
- Teeth with un-restorable crowns
- Root resorption greater than half of the root
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a pulpectomy procedure where the root canals are cleaned and shaped, followed by irrigation with either cinnamon extract or sodium hypochlorite solution.
1 treatment visit (in-person)
Duration - 72 hours
Participants are monitored for post-operative pain at multiple timepoints after the treatment.
Visits at 6, 12, 24, 48, and 72 hours post-treatment
Trial Site Locations
Total: 1 location
1
Cairo university
Cairo, Egypt
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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