Study of DEL-1 and IL-17 Levels in the Eye Fluid of Adults Aged 50 to 80 Undergoing Cataract Surgery with and without Diabetes

What this Trial Is About

Researchers are studying diabetic cataract patients to understand how diabetes-related inflammation affects the eye. The study compares levels of two molecules, DEL-1 and IL-17, in the eye fluid of patients with diabetic cataracts and those with cataracts but no diabetes. DEL-1 is involved in blood vessel health and inflammation control, while IL-17 promotes inflammation and plays a role in immune response. This work aims to uncover biochemical changes linked to diabetes and eye disease. During cataract surgery, a small amount of eye fluid will be collected from both diabetic and non-diabetic patients. This fluid will be tested for DEL-1 and IL-17 levels using a laboratory method called ELISA. The study includes two groups diabetic cataract patients who have had diabetes for at least five years, and non-diabetic cataract patients. The collection occurs before any surgical fluid is added to the eye. Participants will undergo cataract surgery with sampling of eye fluid during the operation. Researchers will measure DEL-1 and IL-17 levels and look for relationships between these molecules and factors like blood sugar control HbA1c and patient demographics. The study assesses these markers during the surgery period, aiming to better understand inflammation in diabetic eye disease. The total participation involves the scheduled surgery and perioperative assessments.

Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients