Study of Biomarkers and Wearable Devices to Predict Macronutrient Intake in Adults Aged 50 to 75

What this Trial Is About

Researchers are studying how different macronutrient intakes affect levels of small molecule markers in blood and interstitial fluid. The study aims to validate wearable optical readers and data fusion algorithms that can predict individual-specific macronutrient availability in real time. This trial focuses on healthy adults aged 50 to 75 years, investigating glucose and amino acid metabolism. Participants will attend one screening visit lasting about 2 hours and up to four study days of approximately 14 hours each. On study days, they consume two predefined meals with specific macronutrient compositions six to eight hours apart. Blood samples are taken via an in-dwelling catheter with the arm heated to collect arterialized venous blood. Microdialysis catheters collect samples from the opposite arm to analyze metabolism markers. During the study, body weight, height, and body composition are measured. Participants complete questionnaires on dietary habits, physical activity, and quality of life. Blood and dialysate samples are processed and stored for later analysis of amino acids, fatty acids, glucose, and insulin. The primary outcome is glucose metabolism measured over up to 14 hours per visit, with secondary outcomes including amino acid metabolism. Participants safety and adherence are monitored throughout the study which ends in December 2026.

Evaluation of Biomarkers for Predicting Macronutrient Intake