Actively Recruiting
Evaluation of Brain MRI Changes in Cerebral Palsy Patients
Led by Columbia University · Updated on 2026-05-13
30
Participants Needed
1
Research Sites
314 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time. This will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.
CONDITIONS
Official Title
Evaluation of Brain MRI Changes in Cerebral Palsy Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have multiple MRI scans of brain and/or spinal cord spaced at least 24 months apart
- Be between 18 and 80 years of age with at least one MRI scan after age 18
- No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration
- Included in the Cerebral Palsy Research Network (CPRN) registry
- Diagnosis of cerebral palsy
- Have received at least one past brain MRI scan as part of standard care (patients with two or more brain MRI scans can be included in the retrospective arm only)
You will not qualify if you...
- History of more than one seizure in lifetime
- History of known degenerative genetic disorder
- History of brain tumor, abscess, or multiple sclerosis
- History of moderate or severe head trauma
- History of metal implants in head
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Weinberg Family Cerebral Palsy Center, Columbia University
New York, New York, United States, 10040
Actively Recruiting
Research Team
J
Jason Carmel, MD, PhD
CONTACT
S
Shaker Dukkipati, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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