Actively Recruiting
Evaluation of the Clinical Efficacy and Mechanisms of Cord Plasma Eye Drops in the Treatment of Neuropathic Corneal Pain
Led by Singapore Eye Research Institute · Updated on 2026-05-05
20
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the efficacy and work of action of cord plasma eye drops in the treatment of neuropathic corneal pain (NCP). The main question it aims to answer if the cord plasma eye drops are effective for the treatment of NCP through its neurotrophic and anti-neuroinflammatory effects.
CONDITIONS
Official Title
Evaluation of the Clinical Efficacy and Mechanisms of Cord Plasma Eye Drops in the Treatment of Neuropathic Corneal Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persistent ocular pain or pain-like symptoms (e.g., burning, allodynia, photoallodynia, stinging, hyperalgesia) with at least 30% score on OPAS questionnaire for more than 3 questions, lasting at least 3 months
- Presence of corneal nerve abnormalities such as microneuromas, beading, nerve tortuosity, or decreased nerve fiber density or length on in vivo confocal microscopy
- Minimal or no ocular surface fluorescein staining with NEI and Oxford score less than 2
- Patients who will receive cord plasma eye drops treatment
You will not qualify if you...
- Active ocular surface diseases including active infective keratitis or epithelial defects causing nociceptive pain
- Active anterior or posterior blepharitis
- Other ocular diseases causing pain such as uveitis or ocular inflammatory conditions
- Concurrent treatment with immunosuppressants like topical cyclosporin or steroid eye drops
- Use of oral nonsteroidal anti-inflammatory drugs or other medications affecting pain scores
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Singapore Eye Research Institute
Singapore, Singapore, Singapore, 169856
Actively Recruiting
Research Team
Y
Yu-Chi Liu, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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