Actively Recruiting

Age: 18Years - 65Years
All Genders
NCT05928767

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.

Led by Centre Hospitalier de Lens · Updated on 2026-05-08

200

Participants Needed

5

Research Sites

166 weeks

Total Duration

On this page

Sponsors

C

Centre Hospitalier de Lens

Lead Sponsor

U

University Hospital, Lille

Collaborating Sponsor

AI-Summary

What this Trial Is About

The aim of the study is to demonstrate that "frail" patients, defined as having a CFS score greater than or equal to 5, and "severely" frail patients, defined as having a CFS score between \[6-7\] as defined by Bagshaw et al (14), constitute an independent risk factor (RF) for mortality. In the same way, as an exploratory study, we will try to find out whether clinical frailty constitutes a risk factor for extending the length of hospital stay, the risk of short/medium-term readmission, as has already been demonstrated for patients admitted to intensive care from all causes (15), or for impaired quality of life. The objective is to have a better understanding of the implications and outcomes associated with pre-hospital frailty in young critically ill patients. This analysis will also help to clarify prognoses and contribute to better decision-making on the intensity and proportionality of care, as well as providing better information and helping to manage the expectations of patients and their families in terms of survival prognosis and subsequent quality of life.

CONDITIONS

Official Title

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 18 years and up to 65 years
  • Patient admitted to intensive care - resuscitation
  • Patient admitted for suspected or documented type 3 sepsis
  • Presence of vasopressor amines to maintain MAP > 65mmHg despite filling
  • Lactatemia 2 mmol/L or higher on admission
Not Eligible

You will not qualify if you...

  • Patient moribund on admission
  • Severe pre-existing dementia or cognitive decline preventing independent living, including severe neurodegenerative diseases and mental illness requiring institutionalization
  • Pregnant women or women in labor
  • Patients under guardianship or curatorship
  • Patients deprived of their liberty
  • Patient and/or family unable to speak or understand French

AI-Screening

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Trial Site Locations

Total: 5 locations

1

Ch Germon Et Gauthier

Béthune, France, 62408

Actively Recruiting

2

CH Boulogne sur Mer

Boulogne-sur-Mer, France, 62321

Actively Recruiting

3

CHU de Dijon

Dijon, France, 21079

Actively Recruiting

4

CH de Lens

Lens, France

Actively Recruiting

5

CHU Lille

Lille, France, 59037

Actively Recruiting

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Research Team

G

Guillaume DEGOUY, Dr

CONTACT

M

MELANIE VERLAY

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock. | DecenTrialz