Actively Recruiting
Evaluation of the Clinical Utility of Circulating Biomarkers in Advanced Thyroid Carcinomas
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-03-07
10
Participants Needed
1
Research Sites
263 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is aimed at all adult patients diagnosed with advanced thyroid carcinomas and well-differentiated thyroid carcinomas (DTC) iodine-refractory, well-differentiated iodine-refractory thyroid (RAI-R DTC) metastatic carcinomas that are candidates for systemic therapy. By simple blood sampling and analysis on peripheral blood of circulating DNA (ccf-DNA), circulating RNA (ccf-RNA), and counting and analysis of circulating tumor cells through the use of liquid biopsy, molecular profiling corresponding to those obtained by genomic sequencing on tumor tissue can be arrived at, depending on optimal therapeutic choices
CONDITIONS
Official Title
Evaluation of the Clinical Utility of Circulating Biomarkers in Advanced Thyroid Carcinomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent
- Adult (≥18 years) male or female patients
- Histologic diagnosis of advanced thyroid carcinoma confirmed at centralized review
- Includes well-differentiated, medullary, and anaplastic thyroid carcinomas
- Candidates for initiation of systemic medical therapy
- Availability of biomolecular profiling by multigenic NGS panel on tumor tissue
- Measurable disease by conventional imaging (total body CT with contrast, CT-PET with FDG or F-DOPA)
You will not qualify if you...
- Patients already receiving previous lines of systemic therapy
- Patients not eligible for systemic therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero universitaria Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
M
Margherita Nannini
CONTACT
M
Maria Abbondanza Pantaleo
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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