Actively Recruiting
Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX
Led by Clinical Hub for Interventional Research (CHOIR) · Updated on 2025-12-08
25
Participants Needed
4
Research Sites
247 weeks
Total Duration
On this page
Sponsors
C
Clinical Hub for Interventional Research (CHOIR)
Lead Sponsor
C
Cancer Institute NSW
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to develop new ways to test new drug combinations to kill tumour cells, in patients with acute myeloid leukemia (AML). The main questions it aims to answer are: * Are there new ways to speed up discovery of better treatments for AML patients using AML cells from individual from patients in special mice that can accept human tissue? * Do these mice show treatment responses that are similar to the individual AML patient from whom cells were derived? Participants with AML who are taking standard of care treatment of venetoclax and azacitidine will be asked to donate blood and bone marrow samples for this study.
CONDITIONS
Official Title
Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years and above
- Patients with suspicion of AML requiring screening procedures
- Documented diagnosis of AML by WHO Classification and/or International Consensus Classification
- Includes all AML subtypes regardless of prior therapies or transplant eligibility
- Concurrent participation in other clinical trials allowed
- Documented myeloblast percentage 20% or more in bone marrow or blood within 12 weeks of treatment start
- Planned to begin venetoclax and azacitidine therapy
- Provided written informed consent before any study procedures
You will not qualify if you...
- Any condition that may compromise patient safety, study data quality, or adherence to study procedures as assessed by the Investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Canberra Health Services
Canberra, Australian Capital Territory, Australia, 2605
Actively Recruiting
2
Prince of Wales Hospital
Sydney, New South Wales, Australia, 2031
Actively Recruiting
3
Royal North Shore Hospital
Sydney, New South Wales, Australia, 2065
Not Yet Recruiting
4
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
Research Team
J
John Pimanda, Professor
CONTACT
M
Mark Polizzotto, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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