Comparing General Anesthesia to Two Types of Combined Anesthesia for Opioid Use After Laparoscopic Hysterectomy

What this Trial Is About

This research aims to evaluate and compare the use of general anesthesia versus two types of combined anesthesia on opioid consumption after laparoscopic hysterectomy. The study focuses on managing post-operative pain, which is important to reduce hospital stay, complications, and costs. It also examines how mixing intrathecal fentanyl with spinal anesthesia and morphine may affect pain levels and opioid needs after surgery. Participants receive one of three anesthesia approaches general anesthesia alone, general anesthesia combined with spinal anesthesia using local anesthetic and morphine without fentanyl, or general anesthesia combined with spinal anesthesia including local anesthetic, morphine, and fentanyl. Doses of anesthetics such as propofol, rocuronium, remifentanil, bupivacaine, morphine sulfate, and fentanyl are administered according to specific protocols before and during surgery. Throughout the study, participants are monitored for opioid consumption using patient-controlled analgesia PCA morphine in the first 24 and 48 hours after surgery. Pain levels are assessed at multiple time points using the Visual Analogue Scale VAS, along with evaluations of side effects like nausea, vomiting, pruritus, urinary retention, and quality of recovery using the QoR-15 score. Intraoperative hypotension and opioid use are also recorded. The study is randomized and controlled, with data collected during and after surgery to understand anesthesia effects on pain and recovery.

Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia for Opioid Consumption in Laparoscopic Hysterectomy