Actively Recruiting
Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients
Led by University Hospital, Lille · Updated on 2025-12-23
30
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Bariatric surgery is currently the most efficient treatment for obesity. The sustained weight loss and metabolic improvement seen following Roux-en-Y gastric bypass (RYGB), is explained partly by modifications in hormones including bile acids (BA). After RYGB, an increased total BA pool and a reduction in hepatic cortisol exposure is observed. Hydroxysteroid 11-β dehydrogenase 1 (HSD11B1), steroid 5α-reductases (SRD5A), and steroid 5β-reductases, AKR1D1 (also a BA metabolizing enzyme), are three enzymes involved in the metabolism of cortisol in the liver and are known to participate in metabolic syndrome. Their activity has been shown to be decreased after RYGB. Interestingly, the mechanisms explaining the modification of hepatic cortisol exposure and the activity of theses enzymes after RYGB are unknown. In view of the few data suggesting a link between cortisol metabolism and bile acids, this work aim to study and characterize this link in a context of RYBP
CONDITIONS
Official Title
Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-menopausal women
- Body mass index (BMI) between 35 and 50 kg/m²
- Socially insured
- Ability to give consent
You will not qualify if you...
- Moderate or severe kidney insufficiency
- Liver failure
- Known gallbladder stones
- History of gallbladder removal or planned gallbladder removal during gastric bypass
- Previous bariatric surgery except gastric band or gastric balloon
- History of type 1 diabetes
- Use of oral or inhaled glucocorticoids within the last 6 months
- Use of bile acid treatments such as ursodeoxycholic acid, bile acid sequestrants, statins, or fibrates stopped less than 4 weeks ago
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Huriez - Service d'endocrinologie, diabétologie, nutrition et métabolisme
Lille, France
Actively Recruiting
Research Team
S
Stéphanie ESPIARD, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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