A Clinical Trial of a Psychoeducation Group Intervention for Patients With Borderline Personality Disorder.
Maria Elena Ridolfi, Roberta Rossi, Giorgia Occhialini...
https://pubmed.ncbi.nlm.nih.gov/31917907Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID06913738
A Pragmatic Non-randomized Controlled Study Evaluating the Efficacy of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) Compared to Classic Outpatient Good Psychiatric Management for Borderline Personality Disorder
Led by AddiPsy · Updated on 2025-04-09
154
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
A
AddiPsy
Lead Sponsor
C
Clinique Caradoc
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a new approach called GPM-extended, a dimensional adaptation of Good Psychiatric Management, for treating adults with borderline personality disorder (BPD). This trial compares the effectiveness of GPM-extended with classic Good Psychiatric Management in reducing BPD symptoms and improving related areas such as personality functioning, emotional regulation, and social functioning over one year. The study aims to advance personalized, evidence-based treatments for personality disorders by integrating specific triggers from narcissistic and obsessive-compulsive personality disorders into the treatment for BPD. Participants receive outpatient psychiatric care for one year in one of two groups: either GPM-extended or classic GPM. Both treatments include weekly one-hour individual therapy and psychiatric case management every three weeks. The GPM-extended group focuses therapy on key personality dilemmas like fear of abandonment, self-esteem issues, and control dependency, with tailored group programs including psychoeducation and skills training. The classic GPM group applies a standardized approach focusing on interpersonal sensitivity, with similar group components. During the study, patients are assessed at the start, 4 months, 8 months, and one year using clinician and self-report measures of BPD symptoms and other psychological factors. Researchers monitor changes in symptom severity, personality functioning, social disability, suicidal behaviors, emotional regulation, and therapeutic alliance, among others. The study tracks treatment response and dropout rates while providing comprehensive evaluation throughout the year-long outpatient care.
CONDITIONS
Brief Title
Evaluation of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) for the Treatment of Borderline Personality Disorder
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults (18 years or older)
- Diagnosis of borderline personality disorder with at least 5 out of 9 SCID-II criteria
- Provided written informed consent
- Affiliated with or beneficiary of the French national health insurance system
You will not qualify if you...
- Under 18 years of age
- Presence of comorbid psychotic disorder, intellectual disability, severe antisocial traits, major substance use disorder incompatible with intensive therapy without abstinence, anorexia nervosa with somatic risk, or bipolar disorder in acute manic phase
- Under legal protection (e.g., guardianship or legal safeguard)
- Unable to cooperate or complete required questionnaires
- Not affiliated with or beneficiary of the French national health insurance system
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Outpatient Treatment
Duration - 1 year
Participants receive one year of outpatient treatment for borderline personality disorder. This includes weekly 1-hour individual therapy tailored either to dominant personality dilemmas (GPM-extended) or interpersonal hypersensitivity (Classic GPM), psychiatric case management every 3 weeks, and group programs including psychoeducation and, if needed, skills training for emotion dysregulation.
Weekly individual therapy visits and case management every 3 weeks; group sessions as scheduled
Trial Site Locations
Total: 2 locations
1
Clinique Caradoc
Bayonne, France, 64100
Actively Recruiting
2
Addipsy
Lyon, France, 69007
Actively Recruiting
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Research Team
M
Martin Blay, M.D., M.Sc
F
Frédéric Mazenod
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Dialectical behavior therapy compared with general psychiatric management for borderline personality disorder: clinical outcomes and functioning over a 2-year follow-up.
Shelley F McMain, Tim Guimond, David L Streiner...
https://pubmed.ncbi.nlm.nih.gov/22581157A randomized trial of dialectical behavior therapy versus general psychiatric management for borderline personality disorder.
Shelley F McMain, Paul S Links, William H Gnam...
https://pubmed.ncbi.nlm.nih.gov/19755574Case reports: Using Good Psychiatric Management (GPM) conceptualizations in the dimensional assessment and treatment of personality disorders.
Martin Blay, Ines Benmakhlouf, Miguel Duarte...
https://pubmed.ncbi.nlm.nih.gov/37564248It's time to replace the personality disorders with the interpersonal disorders.
Aidan G C Wright, Whitney R Ringwald, Christopher J Hopwood...
https://pubmed.ncbi.nlm.nih.gov/36595407Longitudinal validation of general and specific structural features of personality pathology.
Aidan G C Wright, Christopher J Hopwood, Andrew E Skodol...
https://pubmed.ncbi.nlm.nih.gov/27819472The structure of personality pathology: Both general ('g') and specific ('s') factors?
Carla Sharp, Aidan G C Wright, J Christopher Fowler...
https://pubmed.ncbi.nlm.nih.gov/25730515The ICD-11 classification of personality disorders: a European perspective on challenges and opportunities.
Bo Bach, Ueli Kramer, Stephan Doering...
https://pubmed.ncbi.nlm.nih.gov/35361271The time has come for dimensional personality disorder diagnosis.
Christopher J Hopwood, Roman Kotov, Robert F Krueger...
https://pubmed.ncbi.nlm.nih.gov/29226598Borderline personality disorder.
John G Gunderson, Sabine C Herpertz, Andrew E Skodol...
https://pubmed.ncbi.nlm.nih.gov/29795363