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Clinical and Radiographic Evaluation of Doxycycline and Doxycycline Loaded Nanoparticles With Gelatin Sponge on Immediate Implant Placement in Esthetic Zone: A Randomized Clinical Trial
Led by Kafrelsheikh University · Updated on 2025-02-05
16
Participants Needed
1
Research Sites
30 weeks
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating how doxycycline nanoparticles combined with a gelatin sponge affect immediate dental implant cases in the esthetic zone. The study aims to determine whether using doxycycline loaded nanoparticles improves clinical and radiographic outcomes compared to using doxycycline with gelatin sponge alone. This randomized clinical trial involves patients needing immediate implant placement in specific anterior teeth areas. Participants will be divided into two groups: one group receives immediate implant placement with the buccal gap filled with doxycycline loaded gelatin nanoparticles plus gelatin sponge, while the other group receives immediate implant placement with doxycycline and gelatin sponge. Each group includes eight patients, and the study focuses on comparing these two treatments. Participants will undergo clinical and radiographic assessments including measurement of marginal bone loss after surgery and at six months. Other evaluations include the Pink Esthetic Score, peri-implant periodontal probing depth, peri-implant vertical bone level, and implant stability at various times before and after surgery. The total study duration includes follow-up assessments up to six months post-surgery to monitor outcomes and safety.
CONDITIONS
Brief Title
Evaluation of Doxycycline Nanoparticle With Gelatin Sponge on Immediate Implant in Esthetic Region
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The presence of non-restorable single-rooted maxillary centrals, canines or premolars.
- Sufficient bone volume.
- Good oral hygiene.
- The remaining space between the socket and the fixture equals or more than 2mm at the coronal third of the socket.
- Sufficient bone width ( 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).
You will not qualify if you...
- Insufficient bone volume.
- Active infection.
- Patients on chemotherapy or radiotherapy.
- Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, 026etc}.
- Pregnant patients.
- Patients with bone diseases.
- Presence of periapical pathology affecting the neighbouring teeth.
- Smokers.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day procedure with follow-up assessments up to 6 months
Participants undergo immediate implant placement with the buccal gap filled either with doxycycline loaded gelatin nanoparticles and gelatin sponge or doxycycline and gelatin sponge.
1 implant placement visit and 3 follow-up visits over 6 months
Trial Site Locations
Total: 1 location
1
Faculty of dentistry kafrelsheikh university
Kafrelsheikh, Kafrelsheikh, Egypt, 12345
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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