Actively Recruiting
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
Led by German University in Cairo · Updated on 2026-01-21
60
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the effect of L-arginine supplementation on cognitive function in geriatric patients. Eligible participants will receive either L-arginine (6 grams once daily) or placebo, and their cognitive performance will be assessed using validated cognitive assessment tools over the study period. The participants will receive the intervention for 4 weeks and followed up every 2 weeks. The primary outcome is improvement in cognitive function, while secondary outcomes include safety, tolerability, and quality of life measures. The findings may provide evidence for the potential role of L-arginine in supporting cognitive health in elderly populations.
CONDITIONS
Official Title
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >60 years
- Montreal Cognitive Assessment (MoCA) test score from 10-25 (mild to moderate cognitive impairment)
You will not qualify if you...
- Presence of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or Multiple Sclerosis
- History of L-arginine intolerance or allergy
- History of asthma
- Recent acute myocardial infarction
- Stroke within the past 1 year
- Changes in medications affecting cognitive function (CNS psychotropics, antihistamines, acetylcholinesterase inhibitors) during the study
- Changes in antihypertensive medications during the study
- Changes in antidiabetic medications during the study
- Changes in antihyperlipidemic medications during the study
- Use of medications for depression, anxiety, or stress that may impact cognition
- Use of nitrates, phosphodiesterase-5 inhibitors, or potassium-sparing diuretics
- Refusal to provide written informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Neurology Department, Al-Azhar University Hospitals
Cairo, Egypt
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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