Actively Recruiting
Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time
Led by CHU de Reims · Updated on 2024-11-13
114
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently intravenous analgesics are used for postoperative analgesia. But the analgesia of these products is tempered by their adverse effects (sedation, confusion, nausea or vomiting, delayed transit, urinary retention and pruritus) which can slow down postoperative recovery. The aim of this study is to evaluate the effectiveness of the administration of local anesthetics via two catheters placed during surgery, but also to study their benefit on respiratory function and therefore on recovery time and morphine sparing.
CONDITIONS
Official Title
Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years old
- Scheduled for on-pump coronary bypass surgery
- Have at least one respiratory risk factor: BMI ≥ 30 kg/m2, active or recent smoker (less than 6 weeks), documented COPD, restrictive ventilatory disorders (CPT less than 80% normal), chronic respiratory failure (PaO2 less than 70 mmHg at rest in ambient air), or age 75 years or older
You will not qualify if you...
- Emergency surgery
- Additional planned surgery during the same intervention (except saphenous vein sampling)
- Aortic dissection
- Preoperative renal failure with GFR less than 30 mL/min/1.73 m2
- Left heart failure with ejection fraction less than 30%
- Pulmonary arterial hypertension above 50 mmHg
- Liver enzyme elevation with ALT or AST more than twice normal
- ASA score 4 or higher
- Coagulopathy
- Anticoagulants or antiplatelet drugs not stopped correctly
- Chronic opioid use or history of drug addiction
- Pregnant or breastfeeding
- Unable to understand the protocol or sign consent
- Known allergy to study substances
- Need for mechanical support like ECMO, intra-aortic balloon pump, or Impella
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Damien JOLLY
Reims, France
Actively Recruiting
Research Team
S
Salvadore MUCCIO
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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