Effectiveness of Closed-loop Spinal Cord Stimulation Therapy for Pain Relief and Quality of Life in Adults with Chemotherapy Induced Peripheral Neuropathy

What this Trial Is About

This research aims to evaluate the effectiveness of closed-loop spinal cord stimulation CL-SCS therapy in patients suffering from painful chemotherapy induced peripheral neuropathy CIPN. CIPN affects up to 40% of chemotherapy patients and causes significant pain. Traditional treatments include medications and other interventions, but evidence for their success is limited. CL-SCS is an advanced method that stimulates nerves in the spinal cord and adjusts stimulation automatically in real time to manage pain. The study involves patients diagnosed with painful CIPN who are scheduled for CL-SCS implantation using the Evoke SCS System. This system sends electrical pulses to the spinal cord, measures nerve responses, and adapts stimulation accordingly. The research observes patients receiving this treatment without a comparison group, tracking effects over time. Participants will be followed for up to 12 months after implantation. Researchers will assess changes in overall pain intensity, pain in arms or legs, CIPN symptoms, medication use, quality of life, and patient satisfaction at 1, 3, 6, and 12 months. Safety will be monitored by recording any serious adverse events during this period. The study collects detailed patient reports and device data to understand CL-SCS therapys impact on pain and quality of life in CIPN patients.

Evaluation of Effectiveness of Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy for Treatment of Chemotherapy Induced Peripheral Neuropathy