Actively Recruiting

Phase 4
Age: 18Years +
FEMALE
NCT06442995

Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.

Led by CHU de Reims · Updated on 2025-12-30

290

Participants Needed

1

Research Sites

149 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Peri-medullary anesthesia is the preferred anesthetic technique for Caesarean surgery. Compared with general anesthesia, it reduces maternal and fetal morbidity and mortality, as well as postoperative pain. However, this technique exposes the patient to the adverse effects of peri-medullary morphine, particularly the risk of postoperative urinary retention. Urinary retention during the first 72 hours after Caesarean section affects around 33% of parturients. This is a particularly debilitating event for parturients, exposing them to the risk of further urinary catheterization, increased theoretical risk of urinary tract infection, traumatic urethral injury, hindered accelerated rehabilitation and altered maternal satisfaction. Several studies have demonstrated the benefits of adding magnesium sulfate to epidural anesthesia for Caesarean sections, notably by reducing postoperative pain. Magnesium sulfate may also have a facilitating effect on postoperative micturition, thanks to its sympathicolytic effect. This hypothesis is supported by a retrospective study carried out in our maternity hospital, which showed a 15% reduction in post-Caesarean urinary retention when women were given magnesium sulfate in addition to the drugs traditionally used for epidurals. This little-known property needs to be clarified

CONDITIONS

Official Title

Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients who have undergone scheduled or emergency Caesarean section surgery under extended epidural anesthesia or combined epidural and spinal anesthesia at the Reims University Hospital.
  • Patients who have just undergone caesarean section and have the epidural catheter in place in the post-interventional monitoring room (SSPI).
  • Patients who agree to take part in the research and have signed the informed consent form
  • Patients of legal age
  • Patients affiliated to a social security scheme
Not Eligible

You will not qualify if you...

  • Minor patients
  • Patients protected by law
  • Patients allergic to local anesthetics, morphine or magnesium sulfate
  • Patients with severe renal insufficiency (GFR < 30 ml/min)
  • Patients with pre-pregnancy mictional disorders
  • Patients with an American Society of Anesthesiologists (ASA) score of 4
  • Patients undergoing caesarean section under general anaesthesia, after failure of perimedullary anaesthesia
  • Patients with accidental intraoperative injury to the urinary tract
  • Patients who have received intravenous magnesium sulfate in the 24 hours preceding cesarean section

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Chu Reims

Reims, France, 51092

Actively Recruiting

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Research Team

M

Maxime Riffault

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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