Actively Recruiting
Evaluation of the Efficacy and Safety of AL2846 Capsule Combined With TQB2450 Injection Compared to Docetaxel Injection in Advanced Non-small Cell Lung Cancer Patients Who Have Failed With Immunotherapy.
Led by Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Updated on 2024-12-30
518
Participants Needed
71
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate the efficacy of AL2846 capsules in combination with TQB2450 injection or Docetaxel injection in patients with advanced NSCLC who have previously failed immune checkpoint inhibitors (anti-PD-1 monoclonal antibody, anti-PD-L1 monoclonal antibody), regardless of new anti-tumor treatment and early termination of treatment.
CONDITIONS
Official Title
Evaluation of the Efficacy and Safety of AL2846 Capsule Combined With TQB2450 Injection Compared to Docetaxel Injection in Advanced Non-small Cell Lung Cancer Patients Who Have Failed With Immunotherapy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 to 75 years
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1
- Body mass index (BMI) of 17 or higher at baseline
- Histologically or cytologically confirmed inoperable locally advanced (stage IIIB/IIIC), metastatic or recurrent (stage IV) non-small cell lung cancer
- Unable to receive radical concurrent chemoradiotherapy
- Failed platinum-based chemotherapy and immune checkpoint inhibitors for incurable locally advanced, metastatic, or recurrent NSCLC
- Received prior systemic therapy for unresectable or not amenable to radical chemoradiation disease
- At least one measurable lesion according to RECIST 1.1 criteria
- Adequate major organ function
You will not qualify if you...
- Diagnosis or current presence of other malignant tumors
- Presence of EGFR mutation, ALK fusion, ROS1 fusion, or other significant driver gene mutations
- Conditions affecting oral drug absorption or use
- Major surgery, incisional biopsy, traumatic injury, or uncured wound/fracture within 28 days before study treatment
- Hyperactive or venous thrombotic events within 6 months
- Severe or uncontrolled diseases
- Previous treatment with other immunotherapies or tyrosine kinase inhibitors
- Any concomitant diseases or conditions judged by the investigator to endanger safety or affect study completion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 71 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230001
Not Yet Recruiting
2
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100021
Not Yet Recruiting
3
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
4
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100050
Not Yet Recruiting
5
Beijing Tiantan Hospital Capital Medical University
Beijing, Beijing Municipality, China, 100070
Not Yet Recruiting
6
Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100080
Actively Recruiting
7
Beijing Cancer Hospital
Beijing, Beijing Municipality, China, 100142
Not Yet Recruiting
8
Beijing Chest Hospital Capital Medical University
Beijing, Beijing Municipality, China, 101149
Not Yet Recruiting
9
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400016
Not Yet Recruiting
10
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China, 400030
Not Yet Recruiting
11
Three Gorges Hospital Affiliated to Chongqing University
Chongqing, Chongqing Municipality, China, 404100
Not Yet Recruiting
12
Fujian Provincial Cancer Hospital
Fuzhou, Fujian, China, 350014
Not Yet Recruiting
13
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China, 361001
Not Yet Recruiting
14
Lanzhou University Second Hospital
Lanzhou, Gansu, China, 730030
Not Yet Recruiting
15
Gansu Provincial Cancer Hospital
Lanzhou, Gansu, China, 730050
Not Yet Recruiting
16
Meizhou People's Hospital
Meizhou, Guangdong, China, 514031
Not Yet Recruiting
17
Cancer Hospital of Shantou University Medical College
Shantou, Guangdong, China, 515000
Not Yet Recruiting
18
Zhongshan City People's Hospital
Zhongshan, Guangdong, China, 528403
Not Yet Recruiting
19
Guigang people's hospital
Guigang, Guangxi, China, 537100
Not Yet Recruiting
20
Liuzhou people's hospital
Liuzhou, Guangxi, China, 545006
Not Yet Recruiting
21
Guangxi Medical University Afiliated Tomor Hospital
Nanning, Guangxi, China, 530021
Not Yet Recruiting
22
Guizhou Provincial People's Hospital
Guiyang, Guizhou, China, 550002
Not Yet Recruiting
23
The Second Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, China, 563006
Not Yet Recruiting
24
The Second Affiliated Hospital of Hainan Medical College
Haikou, Hainan, China, 570216
Not Yet Recruiting
25
Hainan Provincial People's Hospital
Haikou, Hainan, China, 570311
Not Yet Recruiting
26
Affiliated Hospital of Hebei University
Baoding, Hebei, China, 71000
Not Yet Recruiting
27
Affiliated Hospital of Chengde Medical College
Chengde, Hebei, China, 67020
Not Yet Recruiting
28
Tangshan People's Hospital
Tangshan, Hebei, China, 63001
Not Yet Recruiting
29
Daqing Oilfield General Hospital
Daqing, Heilongjiang, China, 163316
Not Yet Recruiting
30
Affiliated Cancer Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150081
Not Yet Recruiting
31
Jiamusi Tuberculosis Hospital (Jiamusi Cancer Hospital)
Jiamusi, Heilongjiang, China, 154007
Not Yet Recruiting
32
Tong Ji Hospital Affiliated To Tongji Medical College HUST
Wuhan, Hubei, China, 430030
Not Yet Recruiting
33
Hubei Cancer Hospital (HBCH)
Wuhan, Hubei, China, 430079
Not Yet Recruiting
34
Xiangyang Central Hospital
Xiangyang, Hubei, China, 441021
Not Yet Recruiting
35
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Not Yet Recruiting
36
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China, 410013
Not Yet Recruiting
37
Hunan Cancer Hospital
Changsha, Hunan, China, 410031
Not Yet Recruiting
38
Hunan Cancer Hospital
Changsha, Hunan, China, 410031
Not Yet Recruiting
39
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China, 17000
Not Yet Recruiting
40
Jiangsu Cancer Hospital
Nanjing, Jiangsu, China, 210009
Not Yet Recruiting
41
Nantong Tumor Hospital
Nantong, Jiangsu, China, 226361
Not Yet Recruiting
42
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China, 221002
Not Yet Recruiting
43
XuZhou Central Hospital
Xuzhou, Jiangsu, China, 221009
Not Yet Recruiting
44
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
Not Yet Recruiting
45
The First Hospital of China Medical University
Shenyang, Liaoning, China, 110001
Not Yet Recruiting
46
Shenyang Tenth People'S Hospital
Shenyang, Liaoning, China, 110096
Not Yet Recruiting
47
The Second Affiliated Hospital of Xi 'an Jiaotong University
Xi'an, Shaanxi, China, 710004
Not Yet Recruiting
48
The First Affiliated Hospital of Air Force Medical University
Xi'an, Shaanxi, China, 710032
Not Yet Recruiting
49
The Second Affiliated Hospital of the Military Medical University of the PLA Air Force
Xi'an, Shaanxi, China, 710038
Not Yet Recruiting
50
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Not Yet Recruiting
51
Binzhou Medical University Hospital
Binzhou, Shandong, China, 256600
Not Yet Recruiting
52
Heze Municipal Hospital
Heze, Shandong, China, 274000
Not Yet Recruiting
53
The Second Hospital of Shandong University
Jinan, Shandong, China, 250000
Not Yet Recruiting
54
Shandong Cancer Hospital&Institute
Jinan, Shandong, China, 250117
Not Yet Recruiting
55
Affiliated Hospital of Jining Medical Uniwersity
Jining, Shandong, China, 272000
Not Yet Recruiting
56
Linyi Cancer Hospital
Linyi, Shandong, China, 276001
Not Yet Recruiting
57
Linyi People's Hospital
Linyi, Shandong, China, 276005
Not Yet Recruiting
58
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China, 266071
Not Yet Recruiting
59
Changzhi People'S Hospital
Changzhi, Shanxi, China, 46000
Not Yet Recruiting
60
Heping Hospital Affiliated to Changzhi Medical College
Changzhi, Shanxi, China, 46000
Not Yet Recruiting
61
Linfen Central Hospital
Linfen, Shanxi, China, 41000
Not Yet Recruiting
62
Shanxi Provincial Cancer Hospital
Taiyuan, Shanxi, China, 30000
Not Yet Recruiting
63
Affiliated Hospital of North SIchuan Medical College
Nanchong, Sichuan, China, 637000
Not Yet Recruiting
64
The second people's hospital of neijiang
Neijiang, Sichuan, China, 641199
Not Yet Recruiting
65
TianJin Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, China, 300060
Actively Recruiting
66
Tianjin Chest Hospital
Tianjin, Tianjin Municipality, China, 300222
Not Yet Recruiting
67
Affiliated Tumor Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China, 830000
Not Yet Recruiting
68
Yunnan Cancer Hospital
Kunming, Yunnan, China, 650106
Not Yet Recruiting
69
The First Affliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310003
Not Yet Recruiting
70
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310018
Not Yet Recruiting
71
Taizhou Enze Medical Center (Group)
Taizhou, Zhejiang, China, 318000
Not Yet Recruiting
Research Team
D
Dingzhi Huang, Doctor
CONTACT
Y
Yi Hu, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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