Actively Recruiting
Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients
Led by Arthrosi Therapeutics · Updated on 2026-03-02
25
Participants Needed
8
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will assess the effect of AR882 and XOI co-administration on sUA lowering as well as reducing tophus burden in the population that has failed uricase treatment (eg., pegloticase). Failed uricase treatment is defined as having an inherent intolerance, anaphylaxis, infusion reaction, antibody development, and/or at least one sUA level that rose to greater than 6 mg/dL while on therapy.
CONDITIONS
Official Title
Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of uncontrolled gout
- Presence of at least 1 clinically visible tophus
- Last uricase infusion occurred 3 or more months ago
- Body weight no less than 50 kg
- Serum creatinine less than 3.0 mg/dL and estimated creatinine clearance 40 mL/min or higher
You will not qualify if you...
- Malignancy within 5 years except successfully treated basal or squamous cell skin cancer
- Pregnant or breastfeeding
- History of symptomatic kidney stones within the past 6 months
- Received pegloticase, rasburicase, or other experimental uricases within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Arthrosi Investigative Site (105)
Margate, Florida, United States, 33063
Actively Recruiting
2
Arthrosi Investigative Site (102)
Miami, Florida, United States, 33155
Actively Recruiting
3
Arthrosi Investigative Site (109)
Tampa, Florida, United States, 33609
Actively Recruiting
4
Arthrosi Investigative Site (106)
Jackson, Mississippi, United States, 39202
Actively Recruiting
5
Arthrosi Investigative Site (108)
Charlotte, North Carolina, United States, 28202
Actively Recruiting
6
Arthrosi Investigative Site (103)
Duncansville, Pennsylvania, United States, 16635
Actively Recruiting
7
Arthrosi Investigative Site (104)
West Lake Hills, Texas, United States, 78746
Actively Recruiting
8
Arthrosi Investigative Site (107)
Bellevue, Washington, United States, 98004
Actively Recruiting
Research Team
D
Director Clinical Operations
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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