Actively Recruiting
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
Led by Vanda Pharmaceuticals · Updated on 2026-02-27
240
Participants Needed
28
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial is investigating iloperidone as a potential treatment for people with uncontrolled hypertension, a condition where blood pressure remains high despite treatment. The study is designed as a multicenter, randomized, double-blind, placebo-controlled Phase 2 trial to evaluate both the effectiveness and safety of iloperidone for this condition. Participants will be randomly assigned to receive either iloperidone or a placebo. The study involves careful monitoring over a treatment period of 4 weeks to assess changes in systolic blood pressure. Both the experimental drug and placebo are given under controlled conditions, and neither the participants nor the researchers know who receives which. During the study, participants' systolic blood pressure will be measured from baseline through week 4 to evaluate treatment response. Safety and any side effects will be monitored closely. The total study duration includes initial screening followed by the 4-week treatment period. Participants will have regular visits for blood pressure measurements and health assessments throughout the trial.
CONDITIONS
Brief Title
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Systolic blood pressure of 130 mmHg or higher despite more than 8 weeks of treatment with one or more antihypertensive medications
You will not qualify if you...
- Confirmed severe hypertension with systolic blood pressure of 180 mmHg or higher or diastolic blood pressure of 120 mmHg or higher
- Unstable heart disease
- Kidney insufficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 weeks
Participants receive iloperidone or placebo to evaluate the efficacy and safety for uncontrolled hypertension.
Weekly visits for 4 weeks
Trial Site Locations
Total: 28 locations
1
Vanda Investigative Site
Phoenix, Arizona, United States, 85053
Not Yet Recruiting
2
Vanda Investigative Site
Tempe, Arizona, United States, 85281
Actively Recruiting
3
Vanda Investigative Site
Tucson, Arizona, United States, 85715
Not Yet Recruiting
4
Vanda Investigative Site
Chula Vista, California, United States, 91910
Actively Recruiting
5
Vanda Investigative Site
Dublin, California, United States, 94568
Actively Recruiting
6
Vanda Investigative Site
Valencia, California, United States, 91355
Not Yet Recruiting
7
Vanda Investigative Site
Walnut Creek, California, United States, 94596
Actively Recruiting
8
Vanda Investigative Site
Doral, Florida, United States, 33172
Not Yet Recruiting
9
Vanda Investigative Site
Fort Myers, Florida, United States, 33912
Actively Recruiting
10
Vanda Investigative Site
Columbus, Georgia, United States, 31904
Actively Recruiting
11
Vanda Investigative Site
Oak Brook, Illinois, United States, 60523
Actively Recruiting
12
Vanda Investigative Site
Tinley Park, Illinois, United States, 60477
Actively Recruiting
13
Vanda Investigative Site
El Dorado, Kansas, United States, 67042
Actively Recruiting
14
Vanda Investigative Site
Wichita, Kansas, United States, 67226
Actively Recruiting
15
Vanda Investigative Site
Lexington, Kentucky, United States, 40509
Actively Recruiting
16
Vanda Investigative Site
Hazelwood, Missouri, United States, 63042
Actively Recruiting
17
Vanda Investigative Site
Las Vegas, Nevada, United States, 89119
Not Yet Recruiting
18
Vanda Investigative Site
Mount Kisco, New York, United States, 10549
Not Yet Recruiting
19
Vanda Investigative Site
Rochester, New York, United States, 14609
Not Yet Recruiting
20
Vanda Investigative Site
Kinston, North Carolina, United States, 28501
Actively Recruiting
21
Vanda Investigative Site
Cincinnati, Ohio, United States, 45212
Actively Recruiting
22
Vanda Investigative Site
Norman, Oklahoma, United States, 73069
Actively Recruiting
23
Vanda Investigative Site
Oklahoma City, Oklahoma, United States, 73112
Not Yet Recruiting
24
Vanda Investigative Site
Charleston, South Carolina, United States, 29414
Actively Recruiting
25
Vanda Investigative Site
Carrollton, Texas, United States, 75006
Not Yet Recruiting
26
Vanda Investigative Site
Salt Lake City, Utah, United States, 84124
Not Yet Recruiting
27
Vanda Investigative Site
Burke, Virginia, United States, 22015
Actively Recruiting
28
Vanda Investigative Site
Norfolk, Virginia, United States, 23502
Actively Recruiting
Research Team
V
Vanda Pharmaceuticals, Inc.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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