Actively Recruiting

Phase 2
Age: 18Years - 65Years
All Genders
NCT07090161

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Led by Vanda Pharmaceuticals · Updated on 2026-02-27

240

Participants Needed

28

Research Sites

58 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

CONDITIONS

Official Title

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 65 years
  • Sitting systolic blood pressure of 130 mmHg or higher despite more than 8 weeks of treatment with one or more antihypertensive therapies
Not Eligible

You will not qualify if you...

  • Confirmed severe hypertension with sitting systolic blood pressure 180 mmHg or higher or diastolic blood pressure 120 mmHg or higher
  • Unstable cardiac disease
  • Renal insufficiency

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 28 locations

1

Vanda Investigative Site

Phoenix, Arizona, United States, 85053

Not Yet Recruiting

2

Vanda Investigative Site

Tempe, Arizona, United States, 85281

Actively Recruiting

3

Vanda Investigative Site

Tucson, Arizona, United States, 85715

Not Yet Recruiting

4

Vanda Investigative Site

Chula Vista, California, United States, 91910

Actively Recruiting

5

Vanda Investigative Site

Dublin, California, United States, 94568

Actively Recruiting

6

Vanda Investigative Site

Valencia, California, United States, 91355

Not Yet Recruiting

7

Vanda Investigative Site

Walnut Creek, California, United States, 94596

Actively Recruiting

8

Vanda Investigative Site

Doral, Florida, United States, 33172

Not Yet Recruiting

9

Vanda Investigative Site

Fort Myers, Florida, United States, 33912

Actively Recruiting

10

Vanda Investigative Site

Columbus, Georgia, United States, 31904

Actively Recruiting

11

Vanda Investigative Site

Oak Brook, Illinois, United States, 60523

Actively Recruiting

12

Vanda Investigative Site

Tinley Park, Illinois, United States, 60477

Actively Recruiting

13

Vanda Investigative Site

El Dorado, Kansas, United States, 67042

Actively Recruiting

14

Vanda Investigative Site

Wichita, Kansas, United States, 67226

Actively Recruiting

15

Vanda Investigative Site

Lexington, Kentucky, United States, 40509

Actively Recruiting

16

Vanda Investigative Site

Hazelwood, Missouri, United States, 63042

Actively Recruiting

17

Vanda Investigative Site

Las Vegas, Nevada, United States, 89119

Not Yet Recruiting

18

Vanda Investigative Site

Mount Kisco, New York, United States, 10549

Not Yet Recruiting

19

Vanda Investigative Site

Rochester, New York, United States, 14609

Not Yet Recruiting

20

Vanda Investigative Site

Kinston, North Carolina, United States, 28501

Actively Recruiting

21

Vanda Investigative Site

Cincinnati, Ohio, United States, 45212

Actively Recruiting

22

Vanda Investigative Site

Norman, Oklahoma, United States, 73069

Actively Recruiting

23

Vanda Investigative Site

Oklahoma City, Oklahoma, United States, 73112

Not Yet Recruiting

24

Vanda Investigative Site

Charleston, South Carolina, United States, 29414

Actively Recruiting

25

Vanda Investigative Site

Carrollton, Texas, United States, 75006

Not Yet Recruiting

26

Vanda Investigative Site

Salt Lake City, Utah, United States, 84124

Not Yet Recruiting

27

Vanda Investigative Site

Burke, Virginia, United States, 22015

Actively Recruiting

28

Vanda Investigative Site

Norfolk, Virginia, United States, 23502

Actively Recruiting

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Research Team

V

Vanda Pharmaceuticals, Inc.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension | DecenTrialz