Actively Recruiting
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Led by Vanda Pharmaceuticals · Updated on 2026-02-27
500
Participants Needed
38
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the efficacy and safety of milsaperidone compared to placebo as adjunctive therapy in patients with Major Depressive Disorder
CONDITIONS
Official Title
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients aged 18 to 65 years, inclusive
- Diagnosed with Major Depressive Disorder according to DSM-5-TR criteria
- Currently experiencing inadequate response to antidepressant therapy as confirmed by the Investigator using the Antidepressant Treatment Response Questionnaire (ATRQ)
You will not qualify if you...
- Any confirmed DSM-5-TR psychiatric diagnosis other than Major Depressive Disorder during the patient's lifetime
- Any confirmed DSM-5-TR psychiatric diagnosis other than Major Depressive Disorder within 6 months before screening
- Any other psychiatric condition (besides Major Depressive Disorder) that has been the main focus of treatment within 12 months before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 38 locations
1
Vanda Investigational Site
Phoenix, Arizona, United States, 85012
Actively Recruiting
2
Vanda Investigational Site
Little Rock, Arkansas, United States, 72211
Actively Recruiting
3
Vanda Investigational Site
Garden Grove, California, United States, 92845
Actively Recruiting
4
Vanda Investigational Site
Lemon Grove, California, United States, 91945
Actively Recruiting
5
Vanda Investigational Site
Orange, California, United States, 92868
Actively Recruiting
6
Vanda Investigational Site
San Jose, California, United States, 95124
Actively Recruiting
7
Vanda Investigational Site
Walnut Creek, California, United States, 94596
Actively Recruiting
8
Vanda Investigational Site
Colorado Springs, Colorado, United States, 80910
Actively Recruiting
9
Vanda Investigational Site
Fort Myers, Florida, United States, 33912
Actively Recruiting
10
Vanda Investigational Site
Miami, Florida, United States, 33135
Active, Not Recruiting
11
Vanda Investigational Site
Miami, Florida, United States, 33173
Actively Recruiting
12
Vanda Investigational Site
Tampa, Florida, United States, 33614
Active, Not Recruiting
13
Vanda Investigational Site
Chicago, Illinois, United States, 60634
Actively Recruiting
14
Vanda Investigational Site
Saint Charles, Missouri, United States, 63304
Actively Recruiting
15
Vanda Investigational Site
Las Vegas, Nevada, United States, 89119
Actively Recruiting
16
Vanda Investigational Site
New York, New York, United States, 10035
Actively Recruiting
17
Vanda Investigational Site
Staten Island, New York, United States, 10314
Actively Recruiting
18
Vanda Investigational Site
Media, Pennsylvania, United States, 19063
Actively Recruiting
19
Vanda Investigational Site
Richardson, Texas, United States, 75080
Actively Recruiting
20
Vanda Investigational Site
Witchita Falls, Texas, United States, 76309
Actively Recruiting
21
Vanda Investigational Site
Bellevue, Washington, United States, 98007
Actively Recruiting
22
Vanda Investigational Site
Sofia, Bulgaria, 1202
Actively Recruiting
23
Vanda Investigational Site
Sofia, Bulgaria, 1618
Actively Recruiting
24
Vanda Investigational Site
Sofia, Bulgaria, 1680
Actively Recruiting
25
Vanda Investigational Site
Targovishte, Bulgaria, 7700
Actively Recruiting
26
Vanda Investigational Site
Varna, Bulgaria, 9020
Actively Recruiting
27
Vanda Investigational Site
Brno, Czechia, 60200
Actively Recruiting
28
Vanda Investigational Site
Pilsen, Czechia, 30100
Actively Recruiting
29
Vanda Investigational Site
Poruba, Czechia, 70800
Actively Recruiting
30
Vanda Investigational Site
Prague, Czechia, 100 00
Actively Recruiting
31
Vanda Investigational Site
Prague, Czechia, 15000
Actively Recruiting
32
Vanda Investigational Site
Prague, Czechia, 16000
Actively Recruiting
33
Vanda Investigational Site
Bialystok, Poland, 15-756
Actively Recruiting
34
Vanda Investigational Site
Bydgoszcz, Poland, 85-794
Actively Recruiting
35
Vanda Investigational Site
Gdansk, Poland, 80-952
Actively Recruiting
36
Vanda Investigational Site
Katowice, Poland, 40-514
Actively Recruiting
37
Vanda Investigational Site
Katowice, Poland, 40-600
Actively Recruiting
38
Vanda Investigational Site
Suchy Las, Poland, 62-002
Actively Recruiting
Research Team
V
Vanda Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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