Actively Recruiting
Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
Led by Vertex Pharmaceuticals Incorporated · Updated on 2026-05-11
176
Participants Needed
93
Research Sites
169 weeks
Total Duration
On this page
Sponsors
V
Vertex Pharmaceuticals Incorporated
Lead Sponsor
Z
Zai Lab (Shanghai) Co., Ltd. (for China only)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).
CONDITIONS
Official Title
Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with primary membranous nephropathy confirmed by a historical biopsy or biopsy performed during screening
You will not qualify if you...
- Known hypersensitivity to the investigational medicinal product or any of its ingredients
- Other protocol defined inclusion/exclusion criteria will apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 93 locations
1
Renal Associates
Montgomery, Alabama, United States, 36117
Actively Recruiting
2
Southwest Kidney Institute, PLC (SKI) - Surprise
Surprise, Arizona, United States, 85374
Actively Recruiting
3
Academic Medical Research Institute (AMRI)
Los Angeles, California, United States, 90022
Actively Recruiting
4
Valiance Clinical Research - Internal Medicine
Tarzana, California, United States, 91356
Actively Recruiting
5
Western Nephrology & Metabolic Bone Disease PC
Arvada, Colorado, United States, 80002
Actively Recruiting
6
Bioresearch Partner
Miami, Florida, United States, 33127
Actively Recruiting
7
CTR Oakwater, LLC
Orlando, Florida, United States, 32806
Actively Recruiting
8
Clinical Site Partners, LLC - Orlando
Winter Park, Florida, United States, 32789
Actively Recruiting
9
DaVita Clinical Research Columbus
Columbus, Georgia, United States, 31904
Actively Recruiting
10
Georgia Nephrology
Lawrenceville, Georgia, United States, 30046
Actively Recruiting
11
CARE Institute-Boise Kidney
Boise, Idaho, United States, 83706
Actively Recruiting
12
NANI Research
Hinsdale, Illinois, United States, 60521
Actively Recruiting
13
DaVita Clinical Research Edina
Edina, Minnesota, United States, 55435
Actively Recruiting
14
Kidney Specialists of Southern Nevada
Las Vegas, Nevada, United States, 89107
Actively Recruiting
15
Carolina Nephrology Greenville
Greenville, South Carolina, United States, 29605
Actively Recruiting
16
Carolina Nephrology, PA
Spartanburg, South Carolina, United States, 29306
Actively Recruiting
17
El Paso Kidney Specialists
El Paso, Texas, United States, 79902
Actively Recruiting
18
Provecta Research Network
Houston, Texas, United States, 77027
Actively Recruiting
19
DaVita Clinical Research Houston
Houston, Texas, United States, 77054
Actively Recruiting
20
Davita Clinical Research San Antonio
San Antonio, Texas, United States, 78251
Actively Recruiting
21
Utah Kidney Research
Salt Lake City, Utah, United States, 84115
Actively Recruiting
22
Milwaukee Neprologists, SC
Wauwatosa, Wisconsin, United States, 53226
Actively Recruiting
23
St George Private Hospital
Kogarah, Australia
Actively Recruiting
24
University of Newcastle - John Hunter Hospital (JHH)
New Lambton Heights, Australia
Actively Recruiting
25
Freire Pesquisa Clinica
Belo Horizonte, Brazil
Actively Recruiting
26
Santa Casa de Misericordia
Porto Alegre, Brazil
Actively Recruiting
27
Fundação Bahiana de Infectologia
Salvador, Brazil
Actively Recruiting
28
Hospital das Clinicas da Faculdade de Medicina da USP - HC- FMUSP
São Paulo, Brazil
Actively Recruiting
29
The First Affiliated Hospital of Baotou Medical College
Baotou, China
Actively Recruiting
30
Beijing Tsinghua Changgung Hospital
Beijing, China
Actively Recruiting
31
Peking University First Hospital
Beijing, China
Actively Recruiting
32
The First Affiliated Hospital of Bengbu Medical University
Bengbu, China
Actively Recruiting
33
The Second Norman Bethune Hospital of Jilin University
Changchun, China
Actively Recruiting
34
Xiangya Hospital of Central South University
Changsha, China
Actively Recruiting
35
Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People's Hospital
Chengdu, China
Actively Recruiting
36
Dalian Municipal Central Hospital
Dalian, China
Actively Recruiting
37
Dongguan People's Hospital
Dongguan, China
Actively Recruiting
38
Fuyang People's Hospital
Fuyang, China
Actively Recruiting
39
Guangdong Provincial People's Hospital
Guangzhou, China
Actively Recruiting
40
The First Affiliated Hospital,Sun Yat-sen University
Guangzhou, China
Actively Recruiting
41
The 2nd Affiliated Hospital of Harbin Medical University
Harbin, China
Actively Recruiting
42
The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University
Huai'an, China
Actively Recruiting
43
The Second Qilu Hospital of Shandong University
Jinan, China
Actively Recruiting
44
Liu Zhou Works Hospital
Liuzhou, China
Actively Recruiting
45
The First Affiliated Hospital of Nanchang University
Nanchang, China
Actively Recruiting
46
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China
Actively Recruiting
47
Nanyang Central Hospital
Nanyang, China
Actively Recruiting
48
The First Affiliated Hospital of Ningbo University
Ningbo, China
Actively Recruiting
49
Renji Hospital Shanghai Jiaotong University School of Medicine
Shanghai, China
Actively Recruiting
50
Shanghai General Hospital
Shanghai, China
Actively Recruiting
51
The First Hospital of Hebei Medical University
Shijiazhuang, China
Actively Recruiting
52
The Fourth Hospital of Hebei Medical Univesrsity
Shijiazhuang, China
Actively Recruiting
53
The Second Hospital of Hebei Medical University
Shijiazhuang, China
Actively Recruiting
54
Tai'an City Central Hosptial
Tai’an, China
Actively Recruiting
55
Weifang People's Hospital
Weifang, China
Actively Recruiting
56
Wuxi People's Hospital
Wuxi, China
Actively Recruiting
57
The First Affiliated Hospital of Xi 'an Jiaotong University
Xi'an, China
Actively Recruiting
58
The First Affiliated Hospital of Xiamen University
Xiamen, China
Actively Recruiting
59
Yantai YuHuangDing Hospital
Yantai, China
Actively Recruiting
60
Yichang Central People Hospital
Yichang, China
Actively Recruiting
61
Vseobecna fakultni nemocnice v Praze - Klinika nefrologie
Prague, Czechia
Actively Recruiting
62
Charite - Universitaetsmedizin Berlin Campus Benjamin Frankl
Allemagne, Germany
Actively Recruiting
63
Klinikum St. Georg gGmbH - Nephrology
Leipzig, Germany
Actively Recruiting
64
Universitaetsklinikum Leipzig - Medizinische Klinik und Poliklinik III - Klinik und Poliklinik fuer Endokrinologie, Nephrologie
Leipzig, Germany
Actively Recruiting
65
Universitaetsklinikum Wuerzburg - Innere Medizin, Nephrologie
Würzburg, Germany
Actively Recruiting
66
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, Hungary
Actively Recruiting
67
Beaumont Hospital
Dublin, Ireland
Actively Recruiting
68
University Hospital Galway
Galway, Ireland
Actively Recruiting
69
IRCCS Ospedale Policlinico San Martino
Genova, Italy
Actively Recruiting
70
Azienda Ospedaliera Universitaria Federico II
Naples, Italy
Actively Recruiting
71
Fondazione Salvatore Maugeri - Nefrologia e Dialisi
Pavia, Italy
Actively Recruiting
72
Kanazawa University Hospital
Kanazawa, Japan
Actively Recruiting
73
Kasugai Municipal Hospital
Kasugai, Japan
Actively Recruiting
74
Okayama University Hospital
Okayama, Japan
Actively Recruiting
75
Nagoya University Hospital
Shōwaku, Japan
Actively Recruiting
76
The University of Osaka Hospital
Suita, Japan
Actively Recruiting
77
Fujita Health University
Toyoake-Shi, Japan
Actively Recruiting
78
Hallym University Sacred Heart Hospital
Anyang-si, South Korea
Actively Recruiting
79
Korea University Anam Hospital - Nephrology
Seoul, South Korea
Actively Recruiting
80
Kyung Hee University Hospital at Gangdong - Nephrology
Seoul, South Korea
Actively Recruiting
81
Samsung Medical Center - Nephrology
Seoul, South Korea
Actively Recruiting
82
Severance Hospital, Yonsei University Health System - Nephrology
Seoul, South Korea
Actively Recruiting
83
Yongin Severance Hospital - Nephrology
Yongin-si, South Korea
Actively Recruiting
84
Hospital Universitari Vall D Hebron
Barcelona, Spain
Actively Recruiting
85
Hospital Universitario Reina Sofia
Córdoba, Spain
Actively Recruiting
86
Hospital Ribera Polusa
Lugo, Spain
Actively Recruiting
87
Clinica Universidad de Navarra - Nefrología
Pamplona, Spain
Actively Recruiting
88
Hospital Universitario Virgen de la Macarena - Nefrología
Seville, Spain
Actively Recruiting
89
University Hospital of Derby and Burton NHS Foundation Trust - Royal Derby Hospital
Derby, United Kingdom
Actively Recruiting
90
Doncaster and Bassetlaw Hospitals NHS Foundation Trust - Doncaster Royal Infirmary
Doncaster, United Kingdom
Actively Recruiting
91
NHS Lothian - Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
Actively Recruiting
92
St George's University Hospitals NHS Foundation Trust - St George's Hospital- Renal Medicine
London, United Kingdom
Actively Recruiting
93
The Royal Wolverhampton NHS Trust - New Cross Hospital
Wolverhampton, United Kingdom
Actively Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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