Actively Recruiting
Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy
Led by Vertex Pharmaceuticals Incorporated · Updated on 2026-04-21
300
Participants Needed
47
Research Sites
84 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)
CONDITIONS
Official Title
Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Diagnosis of type 1 or type 2 diabetes mellitus
- Glycosylated hemoglobin A1c (HbA1c) less than or equal to 9%
- Presence of bilateral pain in lower extremities due to diabetic peripheral neuropathy for at least 1 year
You will not qualify if you...
- Painful neuropathy other than diabetic peripheral neuropathy
- History of cardiac dysrhythmias requiring anti-arrhythmia treatment
- History of atherosclerotic events such as myocardial infarction or stroke within the past 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 47 locations
1
Cullman Clinical Trials
Cullman, Alabama, United States, 35055
Completed
2
Trovare Clinical Research - Bakersfield CA
Bakersfield, California, United States, 93301
Completed
3
Eximia Research - San Diego
La Mesa, California, United States, 91942
Completed
4
Paradigm Clincial Research Centers, LLC., Wheat Ridge
Wheat Ridge, Colorado, United States, 80033
Completed
5
Accel Research - Deland
DeLand, Florida, United States, 32720
Completed
6
AMR Fort Myers (The Clinical Study Center)
Fort Myers, Florida, United States, 33912
Completed
7
Velocity Clinical Research - Hallandale Beach
Hallandale, Florida, United States, 33009
Completed
8
Health Awareness, Inc., Jupiter
Jupiter, Florida, United States, 33458
Completed
9
Suncoast Research Associates - Miami
Miami, Florida, United States, 33172
Completed
10
Innovation Medical Research Center - Palmetto
Palmetto Bay, Florida, United States, 33157
Completed
11
Health Awareness, Inc. - Port St. Lucie
Port Saint Lucie, Florida, United States, 34952
Completed
12
Atlanta Center for Medical Research
Atlanta, Georgia, United States, 30331
Completed
13
Accel Research - Decatur
Decatur, Georgia, United States, 30030
Completed
14
Velocity Clinical Research - Boise
Meridian, Idaho, United States, 83642
Completed
15
Healthcare Research Network - Flossmoor IL
Flossmoor, Illinois, United States, 604773027
Completed
16
Quest Research Institute
Farmington Hills, Michigan, United States, 48334
Completed
17
Healthcare Research Network - Hazelwood MO
Hazelwood, Missouri, United States, 63042
Completed
18
Eximia Research - Raleigh
Raleigh, North Carolina, United States, 27607
Completed
19
Velocity Clinical Research - Cleveland
Beachwood, Ohio, United States, 44122
Completed
20
Velocity Clinical Research - Providence
East Greenwich, Rhode Island, United States, 02818
Completed
21
Clinical Trials of South Carolina - Berkeley - Moncks Corner
Moncks Corner, South Carolina, United States, 29461
Completed
22
Gadolin Research
Beaumont, Texas, United States, 77702
Completed
23
Velocity Clinical Research, Dallas
Dallas, Texas, United States, 75230
Completed
24
San Antonio Clinical Trials
San Antonio, Texas, United States, 78240
Completed
25
AMR Norfolk
Norfolk, Virginia, United States, 23502
Completed
26
Centricity Research Brampton
Brampton, Canada
Actively Recruiting
27
OCT Research ULC
Kelowna, Canada
Actively Recruiting
28
Altasciences - Beaumont Clinic Montreal
Montreal, Canada
Actively Recruiting
29
Mount Sinai Hospital - Leadership Sinai Centre for Diabetes (LSCD)
Toronto, Canada
Actively Recruiting
30
Centre Hospitalier Universitaire de Clermont-Ferrand - Site Gabriel-Montpied
Clermont-Ferrand, France
Actively Recruiting
31
CHU de Nîmes - Pain Assessment and Treatment Center
Nîmes, France
Actively Recruiting
32
Hopital Cochin - Rheumatology
Paris, France
Actively Recruiting
33
North Hospital
Saint-Priest-en-Jarez, France
Actively Recruiting
34
Ruhr-Universitaet Bochum - Heart and Diabetes Center
Bad Oeynhausen, Germany
Actively Recruiting
35
FutureMeds GmbH
Berlin, Germany
Actively Recruiting
36
FutureMeds Frankfurt
Offenbach/Main, Germany
Actively Recruiting
37
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy
Actively Recruiting
38
IRCCS Ospedale San Raffaele - InSpe and Division of Neuroscience
Milan, Italy
Actively Recruiting
39
Birmingham Heartlands Hospital - Heartlands Hospital Diabetes Centre and MIDRU
Birmingham, United Kingdom
Actively Recruiting
40
FutureMeds Birmingham
Birmingham, United Kingdom
Actively Recruiting
41
Ninewells Hospital - Endocrinology
Dundee, United Kingdom
Actively Recruiting
42
FutureMeds Glasgow
Glasgow, United Kingdom
Actively Recruiting
43
University of Liverpool - Aintree University Hospital
Liverpool, United Kingdom
Actively Recruiting
44
St Pancras Clinical Research
London, United Kingdom
Actively Recruiting
45
Manchester Diabetes Centre (MDC)
Manchester, United Kingdom
Actively Recruiting
46
George Eliot Hospital NHS Trust
Nuneaton, United Kingdom
Actively Recruiting
47
Royal Hallamshire Hospital - Endocrinology
Sheffield, United Kingdom
Actively Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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