Assessment of Changes in Clinical and Radiological Parameters in Gingival Pockets After Subgingival Application of Lovastatin Gel Combined With Scaling and Root Planing in Healthy Smokers and Non-Smokers with Periodontal Disease

What this Trial Is About

Researchers are evaluating the effect of a 1.2% lovastatin gel applied under the gum to improve outcomes of classic periodontal treatment called scaling and root planing (SRP). The study compares adults with periodontitis who are generally healthy, dividing them into two groups: non-smokers and smokers with at least 5 years of tobacco use. The goal is to assess whether the medicated gel improves gum health more than a placebo gel without medicine. Participants will receive two treatments on different teeth: one tooth will get the lovastatin gel under the gum after SRP cleaning, and another tooth will receive a similar-appearing placebo gel. The study lasts six months, observing differences between smokers and non-smokers and between treated and placebo areas. The treatment is applied directly to gum pockets meeting specific criteria. During the study, participants will have gum health measured by clinical attachment level, probing depth, bleeding index, and plaque index before treatment and up to six months after. Researchers will monitor changes in gum condition and bone defect depth. The study involves regular assessments to track treatment effects and safety over the full six-month period.

Evaluation Of The Efficacy Of Subgingival Application Of Lovastatin Gel As An Adjunct To Non-Surgical Treatment Of Periodontitis In Generally Healthy Smokers And Non-Smokers Patients in Central Europe.