Comparing Intermittent and Continuous Enteral Nutrition to Prevent Organ Failure in ICU Patients on Mechanical Ventilation with Septic Shock

What this Trial Is About

This research investigates the impact of intermittent enteral nutrition compared to continuous enteral nutrition on preventing organ failures in patients with septic shock who require mechanical ventilation in the intensive care unit ICU. It explores how intermittent feeding, aligned with the bodys natural rhythms, may affect protein production, insulin sensitivity, and other metabolic processes during the acute phase of sepsis. Participants are randomly assigned to one of two groups one receiving intermittent enteral nutrition with three 60-minute feeding sessions every 8 hours, and the other receiving continuous enteral nutrition. The treatment lasts for at least seven days during their ICU stay. The study is sponsored by the University Hospital, Rouen. During the study, patients organ function will be monitored using the SOFA score from the start of nutrition to day 7. Researchers will also assess calorie and protein intake, nutritional status, digestive tolerance, infection rates, metabolic responses, neuromuscular weakness, length of hospitalization, survival, and quality of life up to 90 days. Safety and adverse events will be tracked throughout the study period.

Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit