Actively Recruiting
Evaluation of the Electronic Cigarette Withdrawal Syndrome
Led by Johns Hopkins University · Updated on 2025-07-14
150
Participants Needed
1
Research Sites
239 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.
CONDITIONS
Official Title
Evaluation of the Electronic Cigarette Withdrawal Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 to 55 years old
- Good general health as reviewed by the study medical team
- Vital signs within normal range as reviewed by the study medical team
- Negative urine test for illicit drugs (excluding THC) and negative breath alcohol test
- Daily use of a nicotine-containing e-cigarette for at least 6 months
- No regular use of other tobacco products for at least 6 months
- Urine cotinine greater than 100 ng/mL to confirm current nicotine use
- Exhaled breath carbon monoxide less than 6 ppm
- Penn State E-cigarette Dependence score of 4 or higher indicating mild dependence or greater
- Interest in reducing e-cigarette use
You will not qualify if you...
- Psychoactive drug use (other than cannabis, nicotine, alcohol, caffeine) in the past month
- Current use of over-the-counter or prescription medications that may impact safety
- Use of cannabis more than twice per week
- History or current significant medical condition impacting participation or safety
- Current psychiatric condition or substance use disorder (except tobacco use disorder) impacting participation or safety
- Enrollment in another clinical trial
- Positive pregnancy test
- Currently using nicotine or tobacco cessation products
- Seizure disorder or traumatic brain injury
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
J
Justin Strickland, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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