Actively Recruiting
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
Led by Hospital Universitari Vall d'Hebron Research Institute · Updated on 2024-11-01
40
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery. The main questions it aims to answer are: * Do severely burned patients present with EoT before undergoing burn debridement surgery? * Does the surgical intervention worsen EoT, leading to increased postoperative syndecan 1 (sdc 1) levels compared to preoperative levels? Participants will: * Undergo debridement surgery where the total area of debrided and donor sites covers 20% or more of the Total Body Surface Area (TBSA). * Have their sdc 1 levels measured before and after surgery. * Have perioperative factors analyzed to assess their impact on endothelial damage and glycocalyx functionality. This study aims to provide insight into how surgical resuscitation affects the endothelial glycocalyx in severely burned patients.
CONDITIONS
Official Title
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old with burned TBSA greater than or equal to 20%
- Patients who will undergo debridement of at least 20% of the burned TBSA including the debrided area and donor site
You will not qualify if you...
- Under 18 years old
- Pregnant women
- Patient refusal
- Polytraumatized patients
- Electrical or chemical burns
- Patients with complicated heart disease (decompensated heart failure NYHA class IV, LVEF < 40%, or severe valvular disease)
- Patients with renal disease on hemodialysis/hemofiltration or with GFR < 30 ml/min/1.73m2
- Patients with liver cirrhosis (Child A, B, and C)
- Patients with chronic inflammatory diseases (autoimmune disease)
- Patients on chronic corticosteroids or immunosuppressants
- Patients requiring reintervention for debridement surgery who have already been included during their first surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital Universitari Vall d'Hebron
Barcelona, Spain, Spain, 08035
Actively Recruiting
Research Team
L
Laura Pons Pellicé, MD
CONTACT
L
Luis Abarca Vilchez, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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